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ProteomicsRIT1 oncoproteins escape LZTR1-mediated proteolysis
These data accompany our publication "RIT1 oncoproteins escape LZTR1-mediated proteolysis" (Castel P., et al. Science, 2019). Experiment 1: Identification of LZTR1 as an interacting partner of RIT1 Q Exactive Plus P20161208-02 FLAG GFP P20161208-03 FLAG RIT1 LTQ Orbitrap Velos ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-14 | MSV000083444 | MassIVE
ProteomicsIntegrative proteomic and transcriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1
Lo A, Holmes K, Mundt F, Moorthi S, Fung I, Fereshetian S, Watson J, Carr SA, Mertins P, Berger A. Aberrant activation of RAS oncogenes is a prevalent event in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. Recently, we identified somatic mutation of the RAS-family G...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-03 | MSV000085225 | MassIVE
ProteomicsAffinity purification MS of human Ubiquitin-tagged RIT1
Human RIT1 was tagged with HA tag + N or C terminal ubiquitin (HA-Ubiqutin-RIT1 and HA-RIT1-Ubiqutin) and compared with empty vector (EV) or S35N/M90I RIT1 mutant (HA-RIT1 S35N/M90I). The constructs were expressed in human 293T cells and affinity purified using HA beads. RIT1 interacting proteins we...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD047228 | Pride
Human Ubiquitin Rit1 
GenomicsExpression of RIT1 M90I in primary cardiomyocytes
Expression of RIT1 M90I in primary cardiomyocytes
PRJNA854086 | ENA
GenomicsTranscriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1
Transcriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1
PRJNA610636 | ENA
GenomicsRIT1 drives lung oncogenic transformation and is an actionable target in lung adenocarcinoma [PDX]
RIT1 drives lung oncogenic transformation and is an actionable target in lung adenocarcinoma [PDX]
PRJNA1228518 | ENA
GenomicsRIT1 drives lung oncogenic transformation and is an actionable target in lung adenocarcinoma [H2110]
RIT1 drives lung oncogenic transformation and is an actionable target in lung adenocarcinoma [H2110]
PRJNA1228516 | ENA
TranscriptomicsExpression of RIT1 M90I in primary cardiomyocytes
To investigate the impact of mutant RIT1 expression in cardiac cells, we isolated neonatal cardiomyocytes from mice harbouring an engineered Rit1 locus with Cre recombinase-inducible expression of the pathogenic variant Rit1M90I. Upon isolation, cardiomyocytes were treated with adenoviruses encoding...
ORGANISM(S): Mus musculus 
2022-12-01 | GSE207188 | GEO
UnknownRIT1 oncoproteins escape LZTR1-mediated proteolysis.
Not available
S-EPMC6986682 | biostudies-literature
TranscriptomicsRIT1 drives lung oncogenic transformation and is an actionable target in lung adenocarcinoma [PDX]
RIT1 is a small GTPase of the RAS family and RIT1 mutations have been identified in lung cancer, leukemias, and the developmental disorder Noonan syndrome. Mutations in RIT1 lead to increased levels of this oncoprotein due to impaired proteolysis, resulting in dysregulation of RAS/MAPK and other pat...
ORGANISM(S): Homo sapiens 
2025-05-08 | GSE290503 | GEO
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