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ProteomicsBC-APPS1: Anti-progestin therapy targets hallmarks of breast cancer risk through epithelial-stromal remodelling
Breast cancer (BC) is the leading cause of women's cancer death worldwide. Here, in the BC – Anti Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assess whether progesterone receptor antagonism with ulipristal acetate (UA) for 12 weeks reduces surrogate markers of BC risk in 24 premenopausa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD067122 | Pride
Prevention Breast cancer Laser capture proteomics 
TranscriptomicsSessile serrated adenomas and conventional adenomas of the colon
Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated ...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12514 | biostudies-arrayexpress
ProteomicsPharmacological inhibition of the glucocorticoid regenerating enzyme 11ßhydroxysteroid dehydrogenase type 1 after myocardial infarction preserves cardiac function in a translational pig model
Background and Purpose: Adrenal glucocorticoids (GC) increase acutely after myocardial infarction (MI) and thereafter tissue levels are maintained selectively within cells expressing the enzyme 11ßHydroxysteroid Dehydrogenase type 1 (11ßHSD1) that regenerates active GC from circulating metabolites. ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-01-15 | PXD055401 | Pride
Heart Pig 
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
UnknownAdding Celecoxib With or Without Zoledronic Acid for Hormone-Naive Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.
Not available
S-EPMC5455701 | biostudies-literature
ProteomicsCirculating extracellular vesicle protein biomarker associated with early cancer lesions for early detection of high-grade serous ovarian cancer
Small extracellular vesicles (sEVs), lipid-bilayer delimited particles (50-200 nm) released by cells, are considered a new class of liquid biopsy biomarkers for stealth cancers, e.g., HGSOC. HGSOC originates from the fallopian tube (FT) and progresses from p53 signatures to a precursor lesion called...
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD067228 | Pride
Liquid biopsy biomarker Early cancer detection Extracellular vesicles Proteomics 
TranscriptomicsExpression profile of control, Drosha or Dicer deleted LSKs
To determine genes regulated independently of microRNAs in early haematopoietic progenitors (LSKs) we compared the expression profiles of Drosha or Dicer deficient LSKs and control. Those genes differentially expressed between Drosha or Dicer deficient LSKs are likely regulated indepedently of micro...
ORGANISM(S): Mus musculus 
2015-09-10 | E-GEOD-61305 | biostudies-arrayexpress
ProteomicsTranscriptomic and proteomic analyses show minimal role for mast cell ST2 in primary Heligmosomoides polygyrus bakeri infection
The IL-33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL-33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation, however the role of IL-33-driven mast cell respo...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD074451 | Pride
Interleukin-33  il-33  st2  mast cell  heligmosomoides polygyrus bakeri  proteomics  transcriptomics 
ProteomicsPhosphoproteomic Survey of Human iPSC-derived Lung Alveolar Type 2 Cells Reveals Cytopathogenic Host Responses to SARS-CoV-2 Infection
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, is exerting a massive health and socioeconomic burden. The virus infects pneumocytes, also known as alveolar epithelial type 2 (AT2) cells, ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2020-11-20 | PXD020183 | Pride
Sars-cov-2 Mass spectrometry Human alveolar cells Drug targets Infection Phosphoproteomics Covid-19 Signaling Host pathways Pathogenesis Lung organoids 
ProteomicsDefining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Serous tubal intraepithelial carcinomas (STIC lesions) in the human fallopian tube epithelium (hFTE) are theorized to give rise to high grade serous ovarian cancers (HGSOC). Small extracellular vesicles (sEVs) are known to mediate key signaling in both normal and cancerous tissues, but few ex vivo s...
ORGANISM(S): Homo sapiens (Human) 
2025-07-15 | PXD066017 | Pride
High grade serous ovarian cancer Extracellular vesicles Fallopian tube 
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