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ProteomicsStage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncovers adaptations to a nodular lifestyle
In spite of 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected. The aetiological agent, Onchocerca volvulus, is a filarial nematode with a complex lifecycle involving several distinct stages in ...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2016-05-31 | PXD002889 | Pride
Lc-msms River blindness Onchocerca ochengi 
UnknownHuman infection patterns and heterogeneous exposure in river blindness.
Not available
S-EPMC1257694 | biostudies-literature
UnknownControl, elimination, and eradication of river blindness: scenarios, timelines, and ivermectin treatment needs in Africa.
Not available
S-EPMC4393239 | biostudies-literature
UnknownMacrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.
Not available
S-EPMC7026882 | biostudies-literature
ProteomicsCharacterisation of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite
Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenance and survival in the host. Here we have identified and character...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2020-05-26 | PXD013440 | Pride
Glycosylation Onchocerca Prostaglandin synthase Detoxification Glycans Immune modulation Gsts 
UnknownTherapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness.
Not available
S-EPMC4370165 | biostudies-literature
UnknownMacrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
Not available
S-EPMC7026885 | biostudies-literature
UnknownThe river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.
Not available
S-EPMC4287931 | biostudies-literature
UnknownThe genome of Onchocerca volvulus, agent of river blindness.
Not available
S-EPMC5310847 | biostudies-literature
UnknownAn Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease.
Not available
S-EPMC7830784 | biostudies-literature
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