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ProteomicsA sequence-specific RNA acetylation catalyst
N4-acetylcytidine (ac4C) is a ubiquitous RNA modification incorporated by cytidine acetyltransferase enzymes. Here, we report the biochemical characterization of Thermococcus kodakarensis Nat10 (TkNat10), an RNA acetyltransferase involved in archaeal thermotolerance. We demonstrate that TkNat10's ca...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-10-14 | MSV000096084 | MassIVE
GenomicsNAT10 Promotes Vascular Remodeling via mRNA Ac4c Acetylation
NAT10 Promotes Vascular Remodeling via mRNA Ac4c Acetylation
PRJNA1134350 | ENA
ProteomicsNAT10-dependent N4-acetylcytidine (ac4C) reprograms R-loops and promotes cancer stem cell growth
R-loop remodeling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer to sustain self-renewal and malignancy remains poorly understood. Here, we found that glioblastoma (GBM) stem cells (GSCs) display highly active R-loops compared to differentiated tumor ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD077002 | Pride
Ac4c Cancer stem cell Nat10 Glioblastoma R-loop remodeling Glioblastoma stem cell 
UnknownRole of NAT10-mediated ac4C-modified HSP90AA1 RNA acetylation in ER stress-mediated metastasis and lenvatinib resistance in hepatocellular carcinoma
Not available
S-EPMC9918514 | biostudies-literature
UnknownPACES: prediction of N4-acetylcytidine (ac4C) modification sites in mRNA.
Not available
S-EPMC6668381 | biostudies-literature
UnknownProbing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution.
Not available
S-EPMC9226516 | biostudies-literature
UnknownDynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Not available
S-EPMC8130014 | biostudies-literature
GenomicsProgrammable RNA acetylation with CRISPR-Cas13
Programmable RNA acetylation with CRISPR-Cas13
PRJNA1247425 | ENA
GenomicsNAT10-mediated ac4C RNA acetylation stabilizes CXCL5/DEK mRNA to drive proliferation and metastasis in lung adenocarcinoma [RNA-Seq]
NAT10-mediated ac4C RNA acetylation stabilizes CXCL5/DEK mRNA to drive proliferation and metastasis in lung adenocarcinoma [RNA-Seq]
PRJNA1395020 | ENA
TranscriptomicsNAT10 Promotes Vascular Remodeling via mRNA Ac4c Acetylation
Vascular smooth muscle cells (VSMCs) phenotype switching is a pathological hallmark in various cardiovascular diseases. N4-acetylcytidine (ac4C), catalyzed by N-acetyltransferase 10 (NAT10), is well conserved in the enzymatic modification of RNA. NAT10-mediated ac4C acetylation is involved in variou...
ORGANISM(S): Rattus norvegicus 
2026-07-20 | GSE272001 | GEO
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