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TranscriptomicsExpression data from Drosophila S2 cells depleted of exosome subunits
The exosome complex and its' subunits are vital for proccessing and or degrading many cellular RNAs. We used microarrays to detail the global changes in mRNA levels in response to exosome subunit depletion. RNA was extracted from dsRNA treated S2 cells and hybridized using Affymetrix microarrays. We...
ORGANISM(S): Drosophila melanogaster 
2010-04-12 | E-GEOD-17874 | biostudies-arrayexpress
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide Analysis of Exosome Targets in the Budding Yeast Saccharomyces cerevisiae
Purpose: The exosome plays major roles in RNA processing and surveillance but the in vivo target range and substrate acquisition mechanisms remain unclear. We applied an in vivo cross-linking technique coupled with deep sequencing (CRAC) that captures transcriptome-wide interactions between individu...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-25 | E-GEOD-40046 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of thermosensitive exosome mutants from permissive temperature and various time exposure to restrictive temperature
Transcriptome analyses of thermosensitive exosome mutants from permissive temperature to various time exposure to restrictive temperature.
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-28 | E-MEXP-537 | biostudies-arrayexpress
OtherThe nuclear exosome is active and important during budding yeast meiosis.
Data from ProteomeXchange, PXD ID: PXD001239. File: Meiosis_IP_rep.mzml. Published as part of PLoS One. 2014 Sep 11;9(9):e107648 . From the Abstract: {{i}} ... We have analysed the activity of the nuclear exosome during meiosis by deletion of TRF4, which encodes a key component of the exosome targe...
ORGANISM(S): Yeast 
GPM32310019869 | GPMDB
Resource Reanalysis 
GenomicsThe RNA Exosome Promotes Transcription Termination of backtracked RNA Polymerase II
Large fractions of genomes are expressed in most eukaryotic cells, generating a diverse repertoire of protein-coding and non-coding transcripts. With such complexity, and as the number of mRNA molecules per cell are often low, it is clear that errors anywhere in the gene expression process could hav...
ORGANISM(S): Schizosaccharomyces pombe 
2014-09-20 | E-MTAB-2237 | biostudies-arrayexpress
ProteomicsRST1 and RIPR connect the cytosolic RNA exosome to the SKI complex in Arabidopsis
The RNA exosome is a key 3’-5’ exoribonuclease with evolutionary conserved structure and roles. Its cytosolic functions require the co-factors SKI7 and the Ski complex. Here we demonstrate by co-purification experiments that the ARM repeat protein RESURRECTION1 (RST1) and RST1 INTERACTING PROTEIN (R...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-07-17 | PXD013435 | Pride
Rst1 Exo9 Rna exosome Ski7 Ski complex Exosome complex 
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RNA-Seq]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64991 | biostudies-arrayexpress
ProteomicsAn extended PAXT connection is required for turnover of nuclear polyadenylated RNA in human cells
Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT connection remains poorly defined. By charact...
ORGANISM(S): Homo Sapiens (human) 
2019-10-31 | PXD016070 | JPOST Repository
TranscriptomicsThe roles of 3’-exoribonucleases and the exosome in trypanosome mRNA degradation
The roles of 3’-exoribonucleases and the exosome in trypanosome mRNA degradation; 30 min after actinomycin D +sinefungin, RNAi against CAf1, CNOT10, PAN2. These are really old data that hadn't been deposited.The datasets called RNA1, RNA2, RNA3 and RNA4 are almost certainly, from their location in t...
ORGANISM(S): Trypanosoma brucei brucei 
2021-03-11 | E-MTAB-10260 | biostudies-arrayexpress
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