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ProteomicsProtein interactome of small RNA fragments: identification and functional implications
Populations of small eukaryotic RNAs, in addition to relatively well recognized molecules (such as miRNAs or siRNAs), also contain fragments derived from all classes of constitutively expressed non-coding RNAs. It has been recently demonstrated that the formation and accumulation of RNA fragments (R...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD010075 | Pride
Protein interactome Rna fragments Rna-protein interaction 
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (single embryo)
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75765 | biostudies-arrayexpress
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74537 | biostudies-arrayexpress
GenomicsRNA sequencing of adult mouse brain microvascular fragments
RNA sequencing of adult mouse brain microvascular fragments
PRJNA1456436 | ENA
TranscriptomicsThe ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of measuring gene expression at the level of translation. We present a protocol for genome-wide, quantitative analysis of in vivo translation by deep sequencing. This ribosome pr...
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37744 | biostudies-arrayexpress
TranscriptomicsSKI2 mediates degradation of RISC 5’-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis
A loss-of-function mutant in the SKI2 helicase in Arabidopsis was shown to accumulate 5'-cleavage fragments of several miRNA targets. Small RNAs in ski2 single and ski2/rdr6 double mutants (two biological replicates of each genotype) were next analysed by NGS. The data show that several miRNA target...
ORGANISM(S): Arabidopsis thaliana 
2015-10-20 | E-MTAB-3781 | biostudies-arrayexpress
TranscriptomicsDistinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments
During translation elongation, the ribosome ratchets along its mRNA template, incorporating each new amino acid and translocating from one codon to the next. The elongation cycle requires dramatic structural rearrangements of the ribosome. We show here that deep sequencing of ribosome-protected mRNA...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-10 | E-GEOD-58321 | biostudies-arrayexpress
TranscriptomicsCirculating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma
Global microRNA expression profiling of serum were collected using Agilent miRNA microarrays (G4471A Human, Amadid 29297, Sanger 14) carrying 887 individual human miRNA probes. Two different sources of RNA were analyzed: serum from NMRI-nu/nu mice carrying a xenograft tumor derived from human prima...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-34052 | biostudies-arrayexpress
GenomicsEvaluating Detection of small RNA derived fragments from small RNA-seq data
Evaluating Detection of small RNA derived fragments from small RNA-seq data
PRJNA998797 | ENA
UnknownGenetic bypass of essential RNA repair enzymes in budding yeast.
Not available
S-EPMC5824351 | biostudies-literature
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