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ProteomicsDEAD box RNA helicases are pervasive protein kinase interactors and activators
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins may stimulate protein kinases. To investigate if protein kinase-DDX interaction is a more widespread phenomenon, we conduc...
ORGANISM(S): Homo sapiens (Human) 
2024-03-10 | PXD043289 | Pride
Kinase activators Rna helicases Interactome 
ProteomicsProxitome profiling of a viral suppressors of RNA silencing identifies the DEAD-box RNA helicase RH20 as a positive regulator of antiviral RNA interference in Nicotiana benthamiana
In the prolonged arms race between viruses and their host plants, viruses usually encode viral suppressors of RNA silencing (VSR) to overcome the hosts' defense mechanism by inhibiting RNAi. Barley stripe mosaic virus (BSMV) is an RNA virus characterized by a positive single-stranded genetic structu...
ORGANISM(S): Nicotiana Benthamiana 
2024-02-20 | PXD049705 |
UnknownAMP sensing by DEAD-box RNA helicases.
Not available
S-EPMC3795843 | biostudies-literature
ProteomicsIdentification of RNA helicases that mediate processing of tRNAs into distinct tRNA fragments by LC-MS/MS.
Specific environmental insults cause the limited fragmentation of transfer RNAs (tRNAs) into tRNA-derived small RNAs (tsRNAs), which have been implicated in a wide range of biological processes. tRNA fragmentation results from endonucleolytic activities targeting single-stranded tRNA regions. Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD029869 | Pride
Ddx5x Trna fragments Ddx3x Tsrna Rna helicase enzymes 
GenomicsGenome binding profile of TFIIH helicases XPB and XPD in HT1080 cells
The conserved TFIIH helicases XPB and XPD play key roles in transcription initiation and DNA repair. To investigate the functions of these helicases on a genome-wide scale, we performed ChIP-seq of endogenous XPB and XPD in the HT1080 human fibrosarcoma cell line. 2 ChIP samples and 1 unenriched inp...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-44849 | biostudies-arrayexpress
UnknownRNA folding and functions of RNA helicases in ribosome biogenesis.
Not available
S-EPMC9196750 | biostudies-literature
UnknownRarely at rest: RNA helicases and their busy contributions to RNA degradation, regulation and quality control.
Not available
S-EPMC3590238 | biostudies-literature
UnknownCoupling between the DEAD-box RNA helicases Ded1p and eIF4A.
Not available
S-EPMC4990422 | biostudies-literature
ProteomicsSexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate hollow condensates of DDX3X disease variants
The sex chromosome-encoded RNA helicases DDX3X and DDX3Y play important roles in RNA metabolism. Heterozygous mutations of DDX3X frequently occur in cancers and neurodevelopmental disorders which have strong sex biases. However, how different DDX3X variants impair cellular function in sex specific g...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-26 | MSV000090789 | MassIVE
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
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