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TranscriptomicsRNA-seq reveals that Air1 and Air2 control TRAMP substrate specificity for nuclear RNA surveillance
The Saccharomyces cerevisiae TRAMP4 and TRAMP5 complexes, which consist of the poly(A) polymerase Trf4 or Trf5, respectively, the zinc knuckle proteins Air1 or Air2, and the RNA helicase Mtr4, play a critical role in nuclear RNA surveillance. Although it is known to enhance the nuclease activity of ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-14 | E-GEOD-42231 | biostudies-arrayexpress
ProteomicsSubstrate Specificity of the TRAMP Nuclear Surveillance Complexes
During nuclear surveillance in yeast, the RNA exosome functions together with the TRAMP complexes. These include the DEAH-box RNA helicase Mtr4 together with an RNA-binding protein (Air1 or Air2) and a poly(A) polymerase (Trf4 or Trf5). To better determine how RNA substrates are targeted, we analyze...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-07-02 | PXD017114 | Pride
Trf4 Trf5 Nuclear surveillance Tramp complexes Rna-binding proteins 
TranscriptomicsArgonaute Surveillance and Dicer-Independent priRNAs TriggerRNAi and Heterochromatin Formation
The assembly of fission yeast pericentromeric heterochromatin and generation of small interfering RNAs (siRNAs) from noncoding centromeric transcripts are mutually dependent processes. How this interdependent positive feedback loop is first triggered is a fundamental unanswered question. Here we sho...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-23 | E-GEOD-19734 | biostudies-arrayexpress
UnknownNuclear RNA surveillance: role of TRAMP in controlling exosome specificity.
Not available
S-EPMC3578152 | biostudies-literature
ProteomicsMechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
The S. pombe orthologue of the human PAXT complex, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex which targets cryptic unstable transcripts (CUTs) to the nuclear RNA exosome for degradation. It encompasses the canonical poly(A) polymerase Pla1, responsible for polyadenylation of nascent RNA t...
ORGANISM(S): Fungi Schizosaccharomyces pombe SPK1820 
2022-12-01 | PXD035413 | Pride
Mtrec complex  s. pombe  paxt complex  rna surveilance 
TranscriptomicsLost miRNA surveillance of NOTCH, IGFR pathway-road to sarcomagenesis [Illumina]
The goal of this study was comparative analysis of differentially expressed miRNA and their targets in human chondrosarcoma JJ012 and chondrocytes C28 cell line(control) to elucidate the major signal transduction pathways deregulation in sarcomagenesis. Total RNA extraction was followed by the analy...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-48418 | biostudies-arrayexpress
GenomicsOncogenic CDK13 Mutations Impede Nuclear RNA Surveillance
Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance
PRJNA543289 | ENA
TranscriptomicsLost miRNA surveillance of NOTCH, IGFR pathway-road to sarcomagenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-48420 | biostudies-arrayexpress
GenomicsOncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfChIPseq)
Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfChIPseq)
PRJNA543302 | ENA
GenomicsOncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfRNAseq)
Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfRNAseq)
PRJNA543299 | ENA
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