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ProteomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks
Reactive aldehydes are abundant cytotoxic metabolites, which challenge homoeostasis by crosslinking cellular macromolecules. Whether RNA damage contributes to the toxicity of aldehydes and whether cells possess mechanisms to resolve RNA-protein crosslinks (RPCs) in particular is unknown. Studying th...
ORGANISM(S): Homo sapiens (Human) 
2023-11-13 | PXD038398 | Pride
Formaldehyde Rna-protein crosslinks Ups Rna damage Translational stress 
ProteomicsTranslation-coupled resolution of RNA-protein crosslinks
The aim of the measurements was to investigate RNA damage and RNA-protein crosslinks (RPC) formation in the context of aldehyde-induced toxicity. For this, a photoactivatable-ribonucleoside-enhanced crosslinking (PAR-CL) strategy using 4-thiouridine (4-SU) and UVA-radiation was used. The submitted d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD038332 | Pride
Rna-protein crosslinks 
GenomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_1]
Translation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_1]
PRJNA906951 | ENA
GenomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_2]
Translation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_2]
PRJNA1002346 | ENA
GenomicsAtypical K6-linked ubiquitylation marks toxic RNA-protein crosslinks induced by formaldehyde
Atypical K6-linked ubiquitylation marks toxic RNA-protein crosslinks induced by formaldehyde
PRJNA933609 | ENA
GenomicsTranslation-coupled sensing and degradation of RNA-protein crosslinks
Translation-coupled sensing and degradation of RNA-protein crosslinks
PRJNA1002344 | ENA
ProteomicsDithiothreitol (DTT) acts as a specific, UV-inducible cross-linker in elucidation of protein-RNA interactions
In the present paper, we introduce dithiothreitol (DTT) as a potent protein-RNA cross-linker. To prove this three model systems, a) a small synthetic peptide from smB'/B protein incubated with U1snRNA oligonucleotide, b) in vitro reconstituted 15.5K protein with U4 snRNA oligonucleotide and c) nativ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2022-03-01 | PXD002392 | Pride
Dtt Protein-rna cross-links 
ProteomicsDithiothreitol (DTT) acts as a specific, UV-inducible cross-linker in elucidation of protein-RNA interactions
In the present paper, we introduce dithiothreitol (DTT) as a potent protein-RNA cross-linker. To prove this three model systems, a) a small synthetic peptide from smB'/B protein incubated with U1snRNA oligonucleotide, b) in vitro reconstituted 15.5K protein with U4 snRNA oligonucleotide and c) nativ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2015-10-13 | PXD002656 | Pride
Dtt 
OtherTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_2]
Reactive aldehydes are abundant cytotoxic metabolites, which challenge homoeostasis by crosslinking cellular macromolecules. Aldehyde-induced DNA-DNA crosslinks cause cancer and bone marrow failure in Fanconi anemia, while covalent DNA-protein crosslinks require proteolytic repair to prevent liver t...
ORGANISM(S): Homo sapiens 
2023-11-13 | GSE240135 | GEO
OtherTranslation-coupled sensing and degradation of RNA-protein crosslinks [Ribo-Seq: dataset_1]
Reactive aldehydes are abundant cytotoxic metabolites, which challenge homoeostasis by crosslinking cellular macromolecules. Aldehyde-induced DNA-DNA crosslinks cause cancer and bone marrow failure in Fanconi anemia, while covalent DNA-protein crosslinks require proteolytic repair to prevent liver t...
ORGANISM(S): Homo sapiens 
2023-11-13 | GSE219055 | GEO
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