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ProteomicsComposition and RNA binding specificity of metazoan RNase MRP
Mechanistic studies have revealed ribonuclease (RNase) MRP, a conserved RNA-based enzyme, is crucial for the maturation of ribosomal RNA in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain unknown. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD061658 | Pride
Nepro Ribonuclease (rnase) mrp C18orf21 Ip-ms 
TranscriptomicsRNAi profiling by array of human HEp-2 cells with siRNA-mediated depletion of RNase MRP protein components
To identify mRNA substrates for the human RNase MRP complex, we examined the effects of siRNA-mediated depletion of RNase MRP (and RNase P) on the transcriptome of HEp-2 cells. The expression of two RNase MRP protein components, hPop1 and Rpp40, was knocked-down and after 48 hours mRNA was isolated ...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-TABM-981 | biostudies-arrayexpress
ProteomicsC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
RNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a unique subunit, RPP21, whereas no RNase MRP-specific protei...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD065571 | Pride
Rnase p Rnase mrp Rrna biogenesis 
GenomicsComposition and RNA binding specificity of metazoan RNase MRP
Composition and RNA binding specificity of metazoan RNase MRP
PRJNA1231220 | ENA
GenomicsReversible proliferative arrest induced by rapid depletion of RNase MRP
Reversible proliferative arrest induced by rapid depletion of RNase MRP
PRJNA1066360 | ENA
ProteomicsA disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
Mutations in the human RMRP gene cause Cartilage Hair Hypoplasia (CHH), an autosomal recessive disorder characterized by skeletal abnormalities and impaired T-cell activation. RMRP encodes a non-coding RNA, which forms the core of the RNase MRP ribonucleoprotein complex. In budding yeast, RMRP cleav...
ORGANISM(S): Homo sapiens (Human) 
2021-03-30 | PXD025029 | Pride
Protein-rna interaction  rna-binding sites  uv crosslinking  mass spectrometry  genetic disease  cartilage hair hypoplasia  ribosome synthesis  t cell activation 
OtherComposition and RNA binding specificity of metazoan RNase MRP
Ribonuclease (RNase) MRP is a conserved RNA-based enzyme that is essential for maturation of ribosomal RNA (rRNA) in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain a mystery. Here, we identify NEPRO and C1...
ORGANISM(S): Mus musculus 
2025-08-05 | GSE290995 | GEO
GenomicsC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
C18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
PRJNA1170312 | ENA
UnknownInteractions between subunits of Saccharomyces cerevisiae RNase MRP support a conserved eukaryotic RNase P/MRP architecture.
Not available
S-EPMC2095792 | biostudies-literature
OtherC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
RNase P and RNase MRP are evolutionarily-related ribonucleoprotein complexes that share common protein subunits, but carry out distinct site-specific endonuclease activities. Here, we identify two RNase MRP-specific proteins C18orf21 (RMP24) and Nepro (RMP64). C18orf21 contains a structurally simila...
ORGANISM(S): Homo sapiens 
2025-08-11 | GSE279079 | GEO
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