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TranscriptomicsTGF-b signaling and response
This work evaluates new and specific therapeutic targets and molecular diagnostic markers connected to the TGF-b response system in chronic fibrotic diseases.
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-579 | biostudies-arrayexpress
MetabolomicsJasmonate-mediated stomatal closure under elevated CO2 revealed by time-resolved metabolomics
Foliar stomatal movements are critical for regulating plant water loss and gas exchange. Elevated carbon dioxide (CO2) levels are known to induce stomatal closure. However, the current knowledge on CO2 signal transduction in stomatal guard cells is limited. Here we report metabolomic responses of Br...
2017-04-25 | MTBLS312 | MetaboLights
MetabolomicsQuantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome

INTRODUCTION: Since the beginning of the SARS-CoV-2 pandemic in December 2019 multiple metabolomics studies have proposed predictive biomarkers of infection severity and outcome. Whilst some trends have emerged, the findings remain intangible and uninformative when it comes to n...

2024-04-23 | MTBLS7429 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
no omics definedTranscription profiling of resting and activated human Vg9Vd2 T cells and CD8 ab T cells
Comparing Vg9Vd2 T cells with CD8 ab T cells
To compare the responses of resting and activated human Vg9Vd2 T cells (mainly CD4-CD8-) to those of conventional CD8+ ab T cells, we used Hver2.1.1 microarrays containing ~15,000 cDNAs. CD8 T cells were chosen as the conventional counterpart of huma...
ORGANISM(S): Homo sapiens 
2010-02-28 | E-MEXP-742 | biostudies-arrayexpress
TranscriptomicsGain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome
This SuperSeries is composed of the following subset Series: GSE27331: Gain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [penn1Mb data] GSE27332: Gain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with a...
ORGANISM(S): Homo sapiens 
2011-02-16 | E-GEOD-27333 | biostudies-arrayexpress
MetabolomicsLC-MS analysis of faecal extracts obtained during colorectal cancer resectional surgery

A prospective observational pilot study from right-sided colorectal cancer (RCRC) patients was performed at Imperial College London NHS Trust, UK. Treatment naïve patients undergoing elective resectional surgery for primary RCRCs were recruited. Fresh intra-luminal fecal samples were obtained at ...

2025-07-11 | MTBLS11775 | MetaboLights
TranscriptomicsRibose utilization by the human commensal Bifidobacterium breve UCC2003
Growth of B. breve UCC2003 on ribose leads to the transcriptional induction of the rbsACBDK gene cluster. Generation and phenotypic analysis of an rbsA insertion mutant established that the rbs gene cluster is essential for ribose utilization, and that its transcription is likely regulated by a LacI...
ORGANISM(S): Bifidobacterium breve UCC2003 
2010-05-19 | E-GEOD-17325 | biostudies-arrayexpress
TranscriptomicsThe roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue
Obesity is a major risk factor for the development of insulin resistance and type II diabetes. The nuclear receptors PPAR delta and PPAR gamma play a central role in regulating metabolism in adipose tissue, as well as being targets for the treatment of insulin resistance. The metabolic effects of PP...
ORGANISM(S): Mus musculus 
2011-07-13 | E-GEOD-26207 | biostudies-arrayexpress
TranscriptomicsLIF-Dependent, Pluripotent Stem Cells Established from Inner Cell Mass of Porcine Embryos
The pig is important for agriculture and as an animal model in human and veterinary medicine, yet, despite over 20 years of effort, it has proved a difficult species from which to generate pluripotent stem cells analogous to those derived from mouse embryos. Here we report the production of LIF-depe...
ORGANISM(S): Sus scrofa 
2011-12-02 | E-GEOD-26369 | biostudies-arrayexpress
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