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TranscriptomicsCD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells
Intercellular communication is critical for integrating complex signals in multicellular eukaryotes. Vascular endothelial cells and T lymphocytes closely interact during the recirculation and trans-endothelial migration of T cells. In addition to direct cell-cell contact, we show that T cell deriv...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-56825 | biostudies-arrayexpress
UnknownAnti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype.
Not available
S-EPMC7079027 | biostudies-literature
TranscriptomicsTransforming growth factor-B1 drives differentiation of the embryonic jejunum
Transcription profiling by microarray was performed to pinpoint the roles of transforming growth factor B1 (TGFB1) in embryonic differentiation of the small intestine. An organ culture system in which mouse jejunal rudiments were placed on semipermeable platforms and fed with chemically defined seru...
ORGANISM(S): Mus musculus 
2017-04-03 | E-MTAB-4509 | biostudies-arrayexpress
TranscriptomicsCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-43133 | biostudies-arrayexpress
UnknownActivation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells.
Not available
S-EPMC2118640 | biostudies-literature
UnknownTNF-α blockade induces IL-10 expression in human CD4+ T cells.
Not available
S-EPMC3918582 | biostudies-literature
TranscriptomicsFoxp3 expression is required for the induction of therapeutic tissue tolerance
CD4+Foxp3+ regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGFB dependent manner. Foxp3+ Treg are also required to achieve tolerance to transplanted tissues when induced...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39529 | biostudies-arrayexpress
UnknownBiologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk.
Not available
S-EPMC11452281 | biostudies-literature
UnknownTransient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors.
Not available
S-EPMC11554890 | biostudies-literature
UnknownIntravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).
Not available
S-EPMC4019912 | biostudies-literature
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