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ProteomicsExtensive Three-Dimensional Intratumor Proteomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens
Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOC) and analyzed by mass spectrometry. Unsupervised analyses of protein abundance data rev...
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD026570 | Pride
Laser microdissection Proteomics Heterogeneity High grade serous ovarian cancer Tumor microenvironment 
GenomicsA role for H3K4 mono-methylation in facultative heterochromatin assembly and partitioning of chromatin readers
Mono-methylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Remarkably, we find H3K4me1 at the promoter regions of conditionaly-repressed muscle and stimulus-dependent inflammatory response genes in myoblasts. Durin...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-50590 | biostudies-arrayexpress
MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
GenomicsNational Human Genome Research Institute Tumor Sequencing Project (TSP) - Lung Adenocarcinoma

The Tumor Sequencing Project (TSP) Consortium is a collaboration among participants at the Baylor College of Medicine Human Genome Sequencing Center, the Broad Institute Genome Sequencing Platform, the Dana Farber Cancer Institute, the Memorial Sloan-Kettering Cancer Center, the Genome Seque...

phs000144.v1.p1 | EGA
TranscriptomicsTranscription profiling of mouse MBP Ac 11-11 activated purified CD4+ T cells
Local catabolism of the amino acid tryptophan (Trp) by indoleamine-2,3-dioxygenase (IDO) is considered an important mechanism of regulating T cell immunity. We show that IDO transcription was increased upon stimulation of myelin-specific T cells with tolerogenic altered self-peptides. Catabolites of...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3401 | biostudies-arrayexpress
TranscriptomicsGroup A Streptococcus Gene Expression in Humans with Pharyngitis Using a Microarray
This study represents the first in vivo genome wide analysis of gene epxression of Group A Streptococcus (GAS) in humans with pharyngitis. The micorarray used is a custom microarray that relies on an electrochemical reaction as the measured signal rather than flourescence. Distinct clusters of gene ...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-22436 | biostudies-arrayexpress
TranscriptomicsRNA Sequencing Quantitative Analysis and identification of RNA editing sites of Wild Type and ADAR1 editing deficient (ADAR1E861A) murine fetal liver RNA
Purpose: RNA editing by ADAR1 is essential for hematopoietic development. The goals of this study were firstly, to identify ADAR1-specific RNA-editing sites by indentifying A-to-I (G) mismatches in RNA-seq data compared to mm9 reference genome in wild type mice that were not edited or reduced in edi...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-58917 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of head tissue from Drosophila melanogaster
We sequenced mRNA from head tissue of females and male of Drosophila melanogaster to identify genes differentially expressed between the sexes and sex-specific alternative splicing events. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/...
ORGANISM(S): Drosophila melanogaster 
2010-04-08 | E-GEOD-20348 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of head tissue from Drosophila mojavensis
We sequenced mRNA from head tissue of females and male of Drosophila mojavensis to identify genes differentially expressed between the sexes and sex-specific alternative splicing events. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pa...
ORGANISM(S): Drosophila mojavensis 
2010-04-11 | E-GEOD-20882 | biostudies-arrayexpress
Genomics4dbf9af0-d667-494b-b3d9-c80c112d0527 - samples
high depth WGS sequencing of 8 sites of a RET fusion tumour
EGAD00001006878 | EGA
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