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ProteomicssiRNA-mediated knockdown of StARD phospholipid transfer proteins in HepG2 cells
We used siRNA to individually knock down the human phospholipid transfer proteins STARD2, STARD7 and STARD10 in HepG2 cells and measured the impact on the cellular phospholipid metabolism. We used DIA proteomics to quantify the selective reduction in protein expression levels.
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD072869 | Pride
ProteomicsDynamics of an LPS translocon induced by substrate and an antimicrobial peptide
We investigated the conformational dynamics of the LPS translocon LptDE was using hydrogen-deuterium exchange mass spectrometry. We evaluated the conformational changes of LptDE upon binding of LPS, Re-LPS (an LPS substructure), thanatin, and the membrane lipid POPG. Our data reveal that LPS induces...
ORGANISM(S): Klebsiella pneumoniae 
2020-11-16 | PXD021743 | Pride
Lps Hydrogen-deuterium exchange Hdx-ms Thanatin Lptde 
ProteomicsStructural characterisation of the fungal Pmt4 homodimer - native MS and lipidomics
Protein O-mannosyltransferases (PMTs) are conserved endoplasmic reticulum membrane embedded enzymes responsible for the transfer of mannose from dolichol phosphate-mannose (Dol-P-Man) to serine/threonine-rich protein substrates or unfolded proteins. PMTs from three subfamilies form obligate dimers w...
ORGANISM(S): Saccharomyces cerevisiae Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 
2025-11-19 | PXD061837 | Pride
ProteomicsThe molecular basis of regulation of bacterial capsule assembly by Wzc
Bacterial extracellular polysaccharides (EPSs) play critical roles in virulence as well as representing valuable bioproducts. Many bacteria use a “Wzx-Wzy-dependent” mechanism to assemble EPSs, in a tightly controlled multi-protein process that couples glycan polymerisation at the inner membrane to ...
ORGANISM(S): Escherichia coli 
2021-07-06 | PXD025820 | Pride
Phosphoproteomics Tyrosine autokinase E. coli 
ProteomicsA prokaryotic E2 enzyme imitates the ubiquitin pathway to regulate the antiviral cGAS
The cyclic oligonucleotide-based anti-phage signalling system (CBASS) is a typeof innate prokaryotic immune system. Composed of a cyclic GMP-AMP synthase (cGAS) and CBASS-associated proteins, CBASS utilizes cyclic oligonucleotides to activate antiviral immunity. One major class of CBASS contains a h...
ORGANISM(S): Serratia Marcescens Lct-sm213 
2024-02-27 | PXD050178 |
UnknownImpact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry.
Not available
S-EPMC8527730 | biostudies-literature
UnknownClinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry.
Not available
S-EPMC9440492 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
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