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GenomicsThree distinct patterns of histone H3Y41 phosphorylation mark active genes
The aim of the project was to identify the global distribution of H3Y41ph and correlate its presence with the transcription factor STAT5 and the active histone modification H3K4me3. This was done in human erythroid leukaemia cells (HEL). HEL cells were treated with DMSO or a JAK2 inhibitor (TG101209...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-MTAB-1096 | biostudies-arrayexpress
GenomicsGlutamine methylation on Histone H2A is an RNA Polymerase I dedicated modification
Nucleosomes are decorated with numerous post-translational modifications capable of influencing many DNA processes. Here, we describe a new class of modification, methylation of glutamine, occurring on yeast histone H2A at position 105 (Q105) and human H2A at Q104. We identify Nop1 as the methyltran...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-21 | E-MTAB-1447 | biostudies-arrayexpress
UnknownTissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells.
Not available
S-EPMC12098486 | biostudies-literature
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
UnknownLimited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19.
Not available
S-EPMC8482538 | biostudies-literature
UnknownAMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death.
Not available
S-EPMC9418192 | biostudies-literature
TranscriptomicsHigh throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells.
Considerable interest has been generated for the development through cell-tissue engineering of suitable corneal endothelial graft alternatives, which can potentially alleviate the shortage of corneal transplant material. The advent of less invasive suture-less key-hole surgery options such as Desce...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-44064 | biostudies-arrayexpress
TranscriptomicsInhibition of bromodomain and extra-terminal (BET) recruitment to chromatin as an effective treatment for mixed lineage leukaemia (MLL)-fusion leukaemia
Gene expression changes in MLL leukaemia following I-BET151 treatment. Note: Additional archives available (E-MTAB-774.additional.1.zip and E-MTAB-774.additional.2.zip) containing individual raw files. Select 'Browse all available files' to view.
ORGANISM(S): Homo sapiens 
2011-09-30 | E-MTAB-774 | biostudies-arrayexpress
UnknownMechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3.
Not available
S-EPMC5000080 | biostudies-literature
TranscriptomicsMiR-155 promotes blood-brain barrier dysfunction in neuroinflammation (part 2)
Over-expression of miR-155 induces changes in the pattern of gene expression of hCMEC/D3 cells. hypothesis tested in the present study was that miR-155 constitute an important regulatory control of the brain endothelial response to inflammatory cytokines. To identify miR-155 target genes in brain en...
ORGANISM(S): Homo sapiens 
2014-04-29 | E-GEOD-44693 | biostudies-arrayexpress
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