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TranscriptomicsComparative genomic hybridization of human nasal NK/T-cell Lymphoma (8 tumor samples, 2 cell lines)
A ﾑCartes dﾒIdentite des Tumeursﾒ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net ) | Human genome-wide CIT-aCGH-V6-4.4K : 8 NKTCL biopsies, 2 NKTCL cell lines. Biopsies and cell lines of NK/T-cell lymphoma, nasal-type (NKTCL) were subject to combine...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-TABM-791 | biostudies-arrayexpress
TranscriptomicsTranscriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumours are generally benign. However, many are invasive and some of these are aggressive with high proliferation and recurrence rates. Only metastatic tumours are considered malignant and are rare (0.2%). To identify molecular events associated with the aggressive and malignant phenotypes...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22812 | biostudies-arrayexpress
TranscriptomicsThe S-adenosyl-homosteine hydrolase inhibitor DZNeP unspecifically affects histone methylation patterns in embryos and results in developmental aberrations
3-deazaneplanocin A (DZNeP) is a promising cancer drug affecting the methylation status of histone lysine residues. To investigate the specificity and mode of action of DZNeP, zebrafish embryos displaying high histone methyltransferase activity were cultured with DZNeP and histone methylation (H3K4m...
ORGANISM(S): Danio rerio 
2014-11-21 | E-GEOD-53209 | biostudies-arrayexpress
TranscriptomicsGenomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumors are generally considered as benign. However, many are invasive (45 to 55%) and some are described as aggressive with a high proliferation rate and short post-operative time to recurrence and 0.2% metastasize. The molecular events associated to the progression of the pituitary tumor ...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22615 | biostudies-arrayexpress
TranscriptomicsDevelopmental features of DNA methylation during activation of the embryonic zebrafish genome
Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in zebrafish and is a period of chromatin remodeling. Genome-scale gametic demethylation and remethylation occurs after fertilization, during blastula stages, but how ZGA relates to promoter DNA methylation states is unknown...
ORGANISM(S): Danio rerio 
2012-07-05 | E-GEOD-33236 | biostudies-arrayexpress
TranscriptomicsMarking of the genome by H3K4 methylation prior to embryonic gene activation
Early zebrafish embryo development proceeds first from a maternally transcribed and stored mRNAs, and zygotic gene activation (ZGA) is initiated at the mid-blastula transition (MBT; 1000-cell stage), 3.3 h post-fertilization. Very little is known on how the zygotic genome is programmed for transcr...
ORGANISM(S): Danio rerio 
2011-12-02 | E-GEOD-27314 | biostudies-arrayexpress
TranscriptomicsThe regulon of the pleiotropic transcription factor Spx in Bacillus subtilis
The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to lead to differential expression of numerous genes but direct and indirect regulatory effects could not be distinguis...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2012-09-06 | E-GEOD-35097 | biostudies-arrayexpress
TranscriptomicsIGR_PBI_SOCS1_GE_JP
Suppressor of cytokine signaling (SOCS1) is an inducible negative regulator of cytokine signaling. SOCS1 is expressed in normal colonic epithelium and colon adenocarcinomas. However, the levels of SOCS1 decreased during progression of colon adenocarcinomas, the lowest level being found in the more ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-1742 | biostudies-arrayexpress
TranscriptomicsMapping of H3K4 and H3K27 trimethylation in zebrafish cells (ChIP-chip)
The genomic distribution of post-translationally modified histones in the zebrafish (Danio rerio) genome remain largely unraveled. The objective of this study was to (1) design a microarray covering all zebrafish gene promoters and 5' end of coding regions, and (ii) using these arrrays, map the geno...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-23691 | biostudies-arrayexpress
UnknownMicroelectromechanical Transducer to Monitor High-Doses of Nuclear Irradiation.
Not available
S-EPMC8433841 | biostudies-literature
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