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TranscriptomicsThe orphan nuclear hormone receptor ERR-beta controls rod photoreceptor survival.
Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor ERRβ as selectively expressed in rod photoreceptors. Overexpression of ERRβ induces expression of rod-specific genes in retinas of both wildtype ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21944 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55377 | biostudies-arrayexpress
Transcriptomicssmall RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55376 | biostudies-arrayexpress
ProteomicsMouse rod photoreceptor Prkaa2 knockout phosphoproteomics
Mouse rod photoreceptors isolated from retinas of Prkaa2 rod photoreceptor specific knockout mice were processed for phosphoproteomics to elucidate downstream kinase targets. Prkaa2 is an isoform of the catalytic subunit of AMP-activated protein kinase (AMPK), an essential nutrient-sensing enzyme re...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD045669 | Pride
Mouse  rod photoreceptor  prkaa2  ampk  phosphoproteomics 
TranscriptomicsEffective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.
Microarray analysis of postnatal NrlGFP-expressing rod photoreceptor precursors. NrlGFP positive versus NrlGFP negative at postnatal day 4
ORGANISM(S): Mus musculus 
2013-06-07 | E-MEXP-3922 | biostudies-arrayexpress
ProteomicsMouse rod photoreceptor Prkaa1 knockout phosphoproteomics
Mouse rod photoreceptor specific Prkaa1 knockouts were isolated from retinas and processed for phosphoproteomics to elucidate downstream kinase targets. Prkaa1 is one of the isoforms for the catalytic subunit of AMP-activated protein kinase (AMPK), an essential nutrient sensing enzyme responsible fo...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD045667 | Pride
Mouse Ampk Rod photoreceptors Prkaa1 Phosphoproteomics 
TranscriptomicsTranscription profiling of mouse retina from four genotypes: +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl at P14 and P28
Rorb is essential for rod photoreceptor development in the mouse retina. Using Affymetrix mouse GeneChips, we have generated expression profiles of the +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl retina at P14 and P28. In this dataset, we include the expression data obtained from retina of wt and...
ORGANISM(S): Mus musculus 
2009-10-23 | E-GEOD-16585 | biostudies-arrayexpress
TranscriptomicsAnalysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55393 | biostudies-arrayexpress
TranscriptomicsPhotoreceptor precursors derived from 3D cultures of embryonic stem cells mature and integrate in degenerate retina
To isolate photoreceptor precursors fit for transplantation, we adapted a 3D differentiation protocol that generates neuroretina from mouse ES cells. We used an adeno-associated viral vector (pseudotype2/9)carrying a GFP reporter under the control of a Rhodopsin promoter (AAV2/9.Rhop.GFP)to select r...
ORGANISM(S): Mus musculus 
2013-07-17 | E-MEXP-3921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse retina with ectopic expression of NR2E3 in Nrl-/- animals reveals in vivo function of NR2E3 in establishing photoreceptor identity during mammalian retinal development
Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation. Mutations in NR2E3, a rod-specific orphan nuclear receptor, lead to loss of rods, incr...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5338 | biostudies-arrayexpress
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