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ProteomicsProteomics reveals that the antifungal activity of fenbendazole against Cryptococcus neoformans requires protein kinases.
Cryptococcus neoformans is responsible for over 100,000 deaths annually, and the treatment of this fungal disease is expensive and not consistently effective. Unveiling new therapeutic avenues is crucial. Previous studies have suggested that the anthelmintic drug fenbendazole is an affordable and n...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2024-05-21 | PXD047041 | Pride
Cryptococcus neoformans  antifungal activity  fenbendazole  proteomics  protein kinases 
ProteomicsFungal extracellular vesicles are recoverable across variable ultracentrifugation speeds but display species-specific profiles of sedimentation
Extracellular vesicles (EVs) are central components of fungal biology, yet their isolation commonly relies on ultracentrifugation schemes originally developed for mammalian systems. In Cryptococcus, most EVs carry the capsular polysaccharide glucuronoxylomannan (GXM), raising the possibility that ve...
ORGANISM(S): Cryptococcus neoformans RCT29 
2026-06-29 | PXD076414 | Pride
Fungal extracellular  vesicles  ultracentrifugation  profiles 
ProteomicsProteomic studies on the effects of the deletion of two aminophospholipid translocases in the cellular and extracellular vesicle fractions of Cryptococcus neoformans
Flippases are enzymes responsible for the architecture of eukaryotic membranes, regulating various mechanisms of molecular transport and lipid translocation. In Cryptococcus neoformans, a major fungal pathogen, the aminophospholipid translocase 1 (Apt1) flippase plays roles in fungal virulence, memb...
ORGANISM(S): Cryptococcus neoformans Tu401-MP_1 
2026-06-29 | PXD056961 | Pride
Proteomic deletiontranslocases cellular extracellular vesicle cryptococcus neoformans 
ProteomicsClassical virulence factors do not define Cryptococcus pathogenic diversity
Pathogenic determinants in the Cryptococcus genus have been extensively studied, often using standard laboratory isolates. Here, we analyzed the virulence of ten Cryptococcus isolates from diverse sources, species, and genotypes. These isolates exhibited marked differences in their ability to coloni...
ORGANISM(S): Cryptococcus gattii VGII R265 Cryptococcus neoformans var. neoformans JEC21 
2025-10-20 | PXD065863 | Pride
Diversity Virulence Pathogenic Cryptococcus 
ProteomicsAn anti-adhesive peptide found in extracellular vesicles from Sporothrix brasiliensis and Sporothrix schenckii
Background Sporothrix brasiliensis and Sporothrix schenckii are the main etiological agents of sporotrichosis. These pathogens release extracellular vesicles (EVs), which are key transport structures involved in virulence and host–pathogen interactions. EVs from S. brasiliensis and S. schenckii have...
ORGANISM(S): Sporothrix sp. 
2025-09-15 | PXD066550 | Pride
Small molecules Sporothrix Extracellular vesicles Adhesion Proteome 
ProteomicsDipeptidyl peptidase IV contributes to the pathogenesis of Cryptococcus neoformans
We previously identified isoleucine–proline–isoleucine (IPI) as a small molecule associated with extracellular vesicles (EVs) in Cryptococcus. The administration of IPI controlled experimental cryptococcal infection through mechanisms that remain unknown. IPI is an inhibitor of dipeptidyl peptidase ...
ORGANISM(S): Cryptococcus neoformans 
2026-07-17 | PXD076200 | Pride
MetabolomicsGNPS - Comprehensive Characterization of Extracellular Vesicles by Environmental (Neff) and Clinical (T4) Strains of Acanthamoeba castellanii
Proteomics, lipidomics, and metabolomics analysis of extracellular vesicles secreted by an environmental strain and a clinical strain of Acanthamoeba castellanii.
ORGANISM(S): Acanthamoeba Castellanii (ncbitaxon:5755) 
2024-04-05 | MSV000094477 | GNPS
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