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TranscriptomicsInfection of the larval airway epithelium by Erwinia carotovora
The unsurpassed simplicity of the fruitfly’s airway epithelium, that is made of homogenous epithelial cells only, favours its use as a model to study general features and response characteristics of airway epithelia in general. All epithelial cells are able to launch an immune response as characte...
ORGANISM(S): Drosophila melanogaster 
2010-05-19 | E-GEOD-11444 | biostudies-arrayexpress
GenomicsRUNX1 is a key target gene in t(4;11) leukemias and contributes to gene activation by interacting with the AF4-MLL complex
The Mixed Lineage Leukemia 1 protein (MLL1) is an important epigenetic regulator required for the maintenance of gene activation during development. MLL1 chromosome translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL1 fusion proteins have distinct l...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-42075 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Fat Body of Drosophila melanogaster Subjected to Sir2 Overexpression or Dietary Restriction
Sir2 is the most intensively discussed longevity gene in current aging research. Although the gene encoding for a NAD+-dependent histone deacetylase initially was found to extend lifespan of various organisms ranging from yeast to mammals, serious doubts regarding its role in longevity have been exp...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-45974 | biostudies-arrayexpress
TranscriptomicsTranscriptional regionalization of the fruit fly's airway epithelium
Although airway epithelia are primarily devoted to gas exchange, they have to fulfil a number of different tasks including organ maintenance and the epithelial immune response to fight airborne pathogens. These different tasks are at least partially accomplished by specialized cell types in the epit...
ORGANISM(S): Drosophila melanogaster 
2014-04-01 | E-GEOD-53273 | biostudies-arrayexpress
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in heart tubes of hand[173] null mutants vs. w[1118]
Hand proteins belong to the highly conserved family of basic Helix-Loop-Helix transcription factors and are critical for distinct developmental processes, including cardiogenesis and neurogenesis in vertebrates. In Drosophila melanogaster a single orthologous hand gene is expressed with absence of t...
ORGANISM(S): Drosophila melanogaster 
2015-03-01 | E-GEOD-64429 | biostudies-arrayexpress
UnknownPhosphorylated MED1 links transcription recycling and cancer growth.
Not available
S-EPMC9071494 | biostudies-literature
TranscriptomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (microarray)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33659 | biostudies-arrayexpress
TranscriptomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors
This SuperSeries is composed of the following subset Series: GSE33653: Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq) GSE33659: Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcript...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33660 | biostudies-arrayexpress
UnknownMutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Not available
S-EPMC5819591 | biostudies-literature
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