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ProteomicsPI3Kdelta is selectively inhibited by roginolisib through stabilizing of the C-terminal helix ka12
Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control non-redundant cellular functions, imposing the need to generate isoform-spe...
ORGANISM(S): Homo sapiens (Human) 
2026-06-24 | PXD071872 | Pride
Phosphoinositide 3-kinase Structure Pi3k Roginolisib Hdx-ms Lipid signalling Inhibition 
UnknownThe highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition.
Not available
S-EPMC10907864 | biostudies-literature
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