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ProteomicsIdentify the proteins interacting with STX17
To identify the specific proteins interacting with STX17, HEK293T cells stably expressing Flag-STX17 were lysed and immunoprecipitated with anti-Flag antibody, and eluted for Commassie blue staining and then subjected to mass spectrometric analysis.
ORGANISM(S): Homo sapiens (Human) 
2023-06-24 | PXD041897 | Pride
Stx17 Immunoprecipitation assays 
ProteomicsULK phosphorylation of STX17 controls autophagosome maturation via FLNA
Autophagy is a conserved and tightly regulated intracellular quality control pathway. ULK is a key kinase in autophagy initiation, but whether ULK kinase activity also participates in late stages of autophagy remains unknown. Here, we found that the autophagosomal SNARE protein, STX17, is phosphoryl...
ORGANISM(S): Homo Sapiens 
2023-06-18 | PXD043082 |
ProteomicsSNAP47 acetylation-dependent regulatory mechanism governing autophagosome-lysosome fusion by modulating the recruitment of HOPS to autophagic vacuoles
Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the default SNARE complex mediating autophagosome-lysosome fusi...
ORGANISM(S): Homo Sapiens 
2024-05-13 | PXD052239 |
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