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TranscriptomicsExpression changes between loricrin knockout and wildtype P0
The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the epidermis are aberrantly exposed to late-stage amniotic fluid, which may serve as the signal to upregulate genes that functionally compensate for ...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-41742 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skin from p63 null and wild type mice to identify genes that are directly or indirectly regulated by p63.
In the absence of p63 expression, the epidermis fails to commit to stratification, resulting in aborted skin development. In this study, gene expression profiles of E18.5 p63 null and wt skin, were compared in an effort to identify genes that are directly or indirectly regulated by p63. Experiment ...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3108 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1)
Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse keratinocytes infected with AD and Ad-NotchIC viruses reveals cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 a...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5229 | biostudies-arrayexpress
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