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Proteomics17 -estradiol impedes aortic root dilation and rupture in male Marfan mice
Thoracic aortic aneurysms have a higher prevalence in male patients compared to female patients. Marfan syndrome causes a hereditary form of TAA with dilation of the aortic root. Male patients with Marfan syndrome are more likely than women to have aortic dilation and dissection and mouse models o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-14 | PXD037853 | Pride
Marfan syndrome Estrogen Sex differences Aneurysm 
MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
TranscriptomicsTranscriptome responses to phosphate supply in grafted grapevine
To determine the roles of the scion and the rootstock in regulating grapevine responses to low Pi supply, the short-term (27 h) root transcriptomic responses were quantified using RNA-Seq.
ORGANISM(S): mixed sample 
2020-02-26 | E-MTAB-8678 | biostudies-arrayexpress
TranscriptomicsEvaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping
Background: We have previously used the rat 4 day Complete Freund's Adjuvant (CFA) model to screen compounds with potential to reduce osteoarthritic pain. The aim of this study was to identify genes altered in this model of osteoarthritic pain and use this information to infer analgesic potential o...
ORGANISM(S): Rattus norvegicus 
2010-10-07 | E-GEOD-24431 | biostudies-arrayexpress
TranscriptomicsResponse of grapevine shoot apex expression to grafting with rootstocks
The transcriptional response in the shoot apex to hetero-grafting Cabernet Sauvignon (CS) with the rootstocks 1103 Paulsen (CS/1103P) and Riparia Gloire de Montpellier (CS/RG) compared to the auto-grafted control (CS/CS) four months after grafting. Gene expression profiling was done using the Nimble...
ORGANISM(S): Vitis vinifera 
2014-01-11 | E-MTAB-1523 | biostudies-arrayexpress
MetabolomicsHuman Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case of Yersinia pestis
Metabolomic approaches, such as in clinical applications of living individuals, have shown potential use for solving questions regarding the past when applied to archaeological material. Here, we study for the first time the potential of this Omic approach as applied to metabolites extracted from ar...
2024-03-15 | MTBLS7394 | MetaboLights
MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
TranscriptomicsThe Nicotinic alpha6 Subunit Gene Determines Variability in Chronic Pain Sensitivity and Nicotine Anti- allodynia via Cross-inhibition of P2X2/3 Receptors.
We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mechanical allodynia a prominent symptom of chronic pain. Expression genetics identifies a role for the Chrna6 (alpha 6-nicotinic receptor) gene in pain in...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65997 | biostudies-arrayexpress
UnknownJNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Not available
S-JCBD-201303066 | bioimages
TranscriptomicsGlobal gene expression profiling of the effect of probiotics supplementation in dairy cows
In animal production the use of probiotics supplements to promote animal health is increasing. The objective of this study was to assess the impact of probiotics administration on global gene expression in dairy cows. Lactating Holstein Friesian cows (n=10) from the North Carolina Agricultural and T...
ORGANISM(S): Bos taurus 
2015-11-21 | E-GEOD-75240 | biostudies-arrayexpress
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