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Human tumors often contain slowly proliferating cancer cells that resist treatment but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy ...
ORGANISM(S): Homo sapiens 
Data from ProteomeXchange, PXD ID: PXD001019. Experiment: Dis14, file: folder summary. Published as part of Elife. 2014 Jul 29:e03023 . From the Abstract: {{i}} Aneuploidy causes severe developmental defects and is a near universal feature of tumor cells. Despite its profound effects, the cellular ...
ORGANISM(S): Yeast 
Salmonella enterica serovar Typhimurium is a Gram-negative bacterium, facultative anaerobe and intracellular pathogen that causes enteric fever in mice. Once orally ingested, Salmonella invades and traverse the mucosal intestinal epithelia, where it is phagocytized by spe...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
During exercise there is a site-specific increase in ROS within muscle required for the beneficial adaptive response by activation of specific signalling pathways. Peroxiredoxin 2 (Prdx2), an abundant cytoplasmic 2-Cys peroxidase, is required for the adaptive beneficial hormesis response to H2O2, my...
ORGANISM(S): Caenorhabditis elegans 
2023-03-11 | PXD037698 | Pride

Vitis labrusca L. grapes are largely cultivated in Brazil, but the tropical climate affect negatively the phenols content, especially anthocyanin. Therefore, researches are focusing on increase grape phenols content; with methyl jasmonate application (MeJa) considered a good alternative.

T...

2020-05-26 | MTBLS784 | MetaboLights
We characterized the global response of plants carrying a mitochondrial dysfunction induced by the expression of the unedited form of the ATP synthase 9 subunit. The u-ATP9 transgene driven by A9 and Apetala3 promoters induce mitochondrial dysfunction revealed by a decrease in both oxygen uptake and...
ORGANISM(S): Arabidopsis thaliana 
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