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TranscriptomicsArchitectural complexity of the polyadenylated intestinal transcriptome revealed by hybrid RNA sequencing
We report the complexity of the polyadenylated transcriptome of the mouse intestinal tract assessed by a hybrid RNA-sequencing. We show that 90.72% of the polyA-derived unique reads map to known genes, but 9.28% of reads matched to nonannotated genomic regions. Screening and verification of non-ann...
ORGANISM(S): Mus musculus 
2011-01-06 | E-GEOD-21699 | biostudies-arrayexpress
TranscriptomicsTwo-step RNA sequencing identifies a tissue-specific landscape of sense/antisense transcription
We report the complexity of the polyadenylated transcriptome of the mouse intestinal tract assessed by two step RNA sequencing. Screening and verification of non-annotated transcriptional units by different RNA-Seq protocols.
ORGANISM(S): Mus musculus 
2011-03-29 | E-GEOD-28207 | biostudies-arrayexpress
TranscriptomicsWide-spread disruption of transcription termination in HSV-1 infection: Next generation sequencing of total and newly transcribed (4sU-RNA) RNA
Primary human foreskin fibroblasts (HFF) were infected with wild-type simplex virus 1 (HSV-1) strain 17 at a multiplicity of infection (MOI) of 10. Newly transcribed RNA was labelled by adding 500µM 4-thiouridine (4sU) to the cell culture media for 1h. Total cellular RNA was isolated using Trizol. N...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-59717 | biostudies-arrayexpress
TranscriptomicsWide-spread disruption of transcription termination in HSV-1 infection: Next-generation sequencing of translational activityd by ribosome profiling
Primary human foreskin fibroblasts (HFF) were infected with wild-type simplex virus 1 (HSV-1) strain 17 at a multiplicity of infection (MOI) of 10. Ribosome profiling was performed at various times during infection with minor modification to the protocol described in Stern-Ginossar N et al., Science...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-60040 | biostudies-arrayexpress
TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of central cells from the Arabidopsis thaliana female gametophyte
This dataset provides the transcriptome of the central cell of the female gametophyte from Arabidopsis thaliana. We sequenced two biological replicates. Each replicate started with a pool of 450 central cells collected using laser-assisted microdissection (LAM). Libraries were prepared as described ...
ORGANISM(S): Arabidopsis thaliana 
2012-01-26 | E-GEOD-29719 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of polyp to jellyfish transition in Aurelia aurita (moon jelly).
Identification of differentially expressed genes during polyp to jellyfish transition in Aurelia aurita
ORGANISM(S): Aurelia aurita 
2013-11-13 | E-MTAB-1960 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of coding RNA from human purified intestinal epithelial samples and organoids derived from foetal and paediatric small and large intestine
Human intestinal epithelial organoids (IEO) culture models are rapidly emerging as novel experimental tools to investigate fundamental aspects of intestinal epithelial (patho)physiology. Cellular source and culture protocols vary between different IEO models and reliable markers for their characteri...
ORGANISM(S): Homo sapiens 
2018-01-20 | E-MTAB-5015 | biostudies-arrayexpress
TranscriptomicsDNA methylation array of human purified intestinal epithelial samples and organoids from paediatric and foetal small and large intestine
Human intestinal epithelial organoids (IEO) culture models are rapidly emerging as novel experimental tools to investigate fundamental aspects of intestinal epithelial (patho)physiology. Cellular source and culture protocols vary between different IEO models and reliable markers for their characteri...
ORGANISM(S): Homo sapiens 
2017-10-31 | E-MTAB-4957 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-28-08-2015-09:49:06:632-229 - samples
RNA-sequencing data from teh hT-RPE-MycER cell line after MYC activation and after MINCR knock-down in conditions of MYC ON or OFF
EGAD00001001598 | EGA
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