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GenomicsGenome-Wide Analysis of Hypodiploid Acute Lymphoblastic Leukemia

Hypodiploid acute lymphoblastic leukemia (ALL) is an aggressive form of leukemia characterized by multiple whole chromosomal losses and very poor outcome. Here we report an integrative genomic analysis that identifies multiple subtypes of hypodiploid ALL characterized by variation in the degree o...

phs000341.v1.p1 | EGA
TranscriptomicsSystems Biology Analysis of Tenofovir 1% Gel in a Phase I Rectal Microbicide Trial
In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-57025 | biostudies-arrayexpress
TranscriptomicsIdentification of Predictive Gene Markers for Multipotent Stromal Cell Proliferation [RT-PCR]
Multipotent stromal cells (MSCs) are known for their distinctive ability to differentiate into different cell lineages such as adipocytes, chondrocytes and osteocytes. They can be isolated from numerous tissue sources including bone marrow, adipose tissue, skeletal muscle and others. Because of th...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-74203 | biostudies-arrayexpress
TranscriptomicsDCP5, a highly conserved P-body-nucleating protein, regulates multiple small RNA-mediated silencing pathways in Arabidopsis (RNA-seq)
MicroRNAs (miRNAs) and small-interfering RNAs (siRNAs) negatively regulate their targets by 1) repressing translation, 2) endonucleolytic RNA cleavage, or 3) DNA methylation resulting in transcriptional silencing. P-body/decapping components are likely required for translational repression, but are ...
ORGANISM(S): Arabidopsis thaliana 
2013-08-16 | E-GEOD-28509 | biostudies-arrayexpress
TranscriptomicsDCP5, a highly conserved P-body-nucleating protein, regulates multiple small RNA-mediated silencing pathways in Arabidopsis (smRNA-seq)
MicroRNAs (miRNAs) and small-interfering RNAs (siRNAs) negatively regulate their targets by 1) repressing translation, 2) endonucleolytic RNA cleavage, or 3) DNA methylation resulting in transcriptional silencing. P-body/decapping components are likely required for translational repression, but are ...
ORGANISM(S): Arabidopsis thaliana 
2013-08-16 | E-GEOD-28512 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of resistant and susceptible Atlantic salmon fry challenged with Infectious Pancreatic Necrosis virus
Infectious Pancreatic Necrosis (IPN) is a highly contagious birnavirus disease of farmed salmonid fish, which often causes high levels of morbidity and mortality. A large genetic component underlying resistance to this disease has been previously described for Atlantic salmon (Salmo salar L.), which...
ORGANISM(S): Salmo salar 
2016-04-07 | E-MTAB-4275 | biostudies-arrayexpress
TranscriptomicsThe Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), characterized by aneuploidy and poor outcome, is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two major subtypes that differ in the severity of aneuploidy, transcriptio...
ORGANISM(S): Homo sapiens 
2013-01-15 | E-GEOD-27237 | biostudies-arrayexpress
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
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