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ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neopla...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD007232 | Pride
Lc-ms/ms Ffpe Oscc 
ProteomicsSaliva peptidome and proteome correlates with oral cancer prognosis
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. Here, we pr...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020111 | Pride
Protease inhibitors Oral squamous cell carcinoma Proteolysis Peptidome Oral cancer 
ProteomicsConnecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD027780 | Pride
Machine learning Head and neck squamous cell carcinoma Buffy coat Saliva Mouth neoplasms Proteomics Lymph node metastasis Prognosis Immune system Biomarkers 
ProteomicsSaliva peptidome correlates with oral cancer prognosis
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. In this wor...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020211 | Pride
Protease inhibitors Oral squamous cell carcinoma Proteolysis Peptidome Oral cancer 
ProteomicsMultisite proteome provides insights into the biology and prognostic markers for head and neck cancer
The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the bio...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD036311 | panorama
ProteomicsMultisite proteome provides insights into the biology and prognostic markers for head and neck cancer
The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the bio...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD027984 | panorama
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