One carbon metabolism supports essential cellular functions, including biomolecule methylation, nucleotide and polyamine synthesis, and redox homeostasis. These processes depend on maintenance of S-adeno-sylmethionine (SAM) homeostasis. Although all methyltransferases consume SAM, only a subset appe...
Summary statistics for a multi-cohort epigenome-wide association study. This includes summary statistics (effect-size, standard error, p-value) for 470,000 methylation markers.
Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...
