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MetabolomicsEffects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS
The standardized extract of Centella asiatica (ECa233) contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Hepatoprotective effect of ECa233 has not yet been reported. The aim of this study was to examine the effect of ECa233 on liver metabolome of rotenone-trea...
2018-10-11 | MTBLS522 | MetaboLights
MetabolomicsExposure to environmental hazard pesticide rotenone triggers redox driven system-wide lipidome alterations and metabolic trade-offs linked to Parkinson’s disease

With the global rise in aging populations, the increasing incidence of neurodegenerative diseases underscores concerns about brain health, with pesticides like rotenone, emerging as key environmental hazardous. The precise mechanism by which chronic environmental concentration of rotenone exposur...

2025-01-28 | MTBLS11699 | MetaboLights
TranscriptomicsTranscriptome analysis of a chronic in vitro model of Parkinsonism
The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND). Many of the mechanisms of action of rotenone are posited mechanisms o...
ORGANISM(S): Homo sapiens 
2012-08-08 | E-GEOD-35642 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis cell cultures treated with rotenone
Effects of rotenone of Arabidopsis cell culture compared to methanol treatment as a control at 0, 3 and 12 hours post treatment
ORGANISM(S): Arabidopsis thaliana 
2008-09-26 | E-MEXP-1797 | biostudies-arrayexpress
TranscriptomicsRotenone susceptibility phenotype in olfactory derived patient cells as a model of idiopathic Parkinson’s disease
Physiologically relevant cellular models are critical for understanding complex pathological processes. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterised by motor and non-motor symptoms. Several cellular models for PD have been developed to reproduce the a...
ORGANISM(S): Homo sapiens 
2016-10-04 | E-MTAB-4164 | biostudies-arrayexpress
ProteomicsMetabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.) mediated neuroprotection in a rotenone-induced cellular model of Parkinsons disease
In the present study we carried out global and targeted metabolomics of differentiated IMR32 cells to study the neuroprotective mechanism of Yashtimadhu (Glycyrrhiza glabra L.) in rotenone induced cellular model of parkinsons disease. Our mass spectrometry data highlighted 2403 and 2934 aligned met...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-31 | MSV000088036 | MassIVE
TranscriptomicsRNA-seq of human fibroblasts during normal aging and during aging with rotenone perturbation
Human fibroblasts at different population doublings were treated with low amounts of rotenone (mild stress) and compared to untreated fibroblasts. Two different cell lines were used (MRC-5, HFF). Illumina sequencing (HiSeq2000) was applied to generate 50bp single-end reads. 60 samples: 3 biological ...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-64553 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of rotenone-induced neuronal death
Rotenone is a naturally occurring toxic substance from the Leguminosa plant and belongs to the group of compounds known as rotenoids (Bové et al., 2005). It is commercially used as a pesticide and is epidemiologically linked to PD. Being lipophilic, rotenone can diffuse across biological membranes ...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22997 | biostudies-arrayexpress
TranscriptomicsCumulative low doses of the organic pesticide rotenone in the adult rat substantia nigra pars compacta
Adult male Sprague Dawley rats (5 month-old at the beginning of the study) were subcutaneously exposed to 0.5 mg.kg/d rotenone or the corresponding solvent (PEG/DMSO, 1/1) for 28 days. At the end of the experiment, animals were sacrificed by decapitation and brains were rapidly taken out within 30-4...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-GEOD-22364 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from HtrA2 knockoutafter rotenone treatment. HtrA2 knockout mice have a movement disorder which may be similar to Parkinsons disease
Cellular stress responses can be activated following functional defects in organelles such as mitochondria and the endoplasmic reticulum. Mitochondrial dysfunction caused by loss of the serine protease HtrA2 leads to a progressive movement disorder in mice and has been linked to parkinsonian neurode...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-13034 | biostudies-arrayexpress
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