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TranscriptomicsHtrA1-dependent proteolysis of TGF-M-NM-2 controls both neuronal maturation and developmental survival
Transforming growth factor-M-NM-2 (TGF-M-NM-2) signalling controls a number of cerebral functions and dysfunctions including synaptogenesis, amyloid-M-NM-2 accumulation, apoptosis and excitotoxicity. Using cultured cortical neurons prepared from either wild type or transgenic mice over-expressing a ...
ORGANISM(S): Homo sapiens 
2008-04-15 | E-GEOD-11162 | biostudies-arrayexpress
TranscriptomicsAtoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells
The morphogen and mitogen, Sonic Hedgehog, activates a Gli1-dependent transcription program that drives proliferation of granule neuron progenitors (GNPs) within the external germinal layer of the postnatally developing cerebellum. Medulloblastomas with mutations activating the Sonic Hedgehog signa...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-19684 | biostudies-arrayexpress
TranscriptomicsThe MYC-MIZ1 interaction defines tumor identity
Medulloblastoma (MB) is the most common malignant brain tumor. MB is a cerebellar tumor that occurs mostly in children between the ages of 3-7 years but also in adults. Human MBs are classified into four subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which with distinc...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-64425 | biostudies-arrayexpress
TranscriptomicsPemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma
We devised a high-throughput, cell-based assay to identify novel therapeutic compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs, grown as neurospheres, were screened against a library of approximately 7,000 compounds including FDA-approved drugs. We identified two FDA-approved drugs, ...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-46406 | biostudies-arrayexpress
ProteomicsGenomic and transcriptomic analysis of medulloblastoma
Tandem mass spectra were processed by PEAKS Studio version 8.5 to detected phosphorylation peptides of mouse cerebellum progenitor.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD019067 | Pride
Cerebellum Phosphorylation Neuron progenitor 
UnknownWhole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration.
Not available
S-EPMC3014266 | biostudies-literature
UnknownAtypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.
Not available
S-EPMC10181938 | biostudies-literature
UnknownPemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma.
Not available
S-EPMC3994669 | biostudies-literature
UnknownFrom PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Not available
S-EPMC10165889 | biostudies-literature
UnknownPatient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource.
Not available
S-EPMC7360541 | biostudies-literature
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