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GenomicsStretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60482 | biostudies-arrayexpress
GenomicsBach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress
TranscriptomicsCD8+ T-cell memory bears the transcriptional imprint of progressive differentiation
The generation of CD8+ T-cell memory is an important aim of immunization. While several distinct subsets of CD8+ T-cell memory have been described, the lineage relationships between effector (EFF), effector memory (EM) and central memory (CM) T cells remain contentious. Specifically, there is contra...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-42459 | biostudies-arrayexpress
TranscriptomicsT cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche
Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T cell-intrinsic expres...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-85131 | biostudies-arrayexpress
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