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ProteomicsRPA70 interactors in BJ and BJ RAS
Activation of oncogenes in healthy cells leads to a permanent cell cycle arrest termed oncogene-induced senescence (OIS) characterized by increased DNA damage and deep epigenetic resetting. Bypassing this premalignant state promotes tumorigenesis. Here, we show that cells entering OIS accumulate hig...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD060652 | Pride
Senescence Rpa70 Rnaseh1 R-loop 
UnknownLIM Protein Ajuba associates with the RPA complex through direct cell cycle-dependent interaction with the RPA70 subunit.
Not available
S-EPMC6015067 | biostudies-literature
UnknownThe small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication.
Not available
S-EPMC9197078 | biostudies-literature
UnknownInteractions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies.
Not available
S-EPMC4251892 | biostudies-literature
UnknownThe DNA double-strand break repair proteins γH2AX, RAD51, BRCA1, RPA70, KU80, and XRCC4 exhibit follicle-specific expression differences in the postnatal mouse ovaries from early to older ages.
Not available
S-EPMC11405603 | biostudies-literature
UnknownSmall molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods.
Not available
S-EPMC3399738 | biostudies-literature
ProteomicsCharacterization of post-mitotic DNA synthesis and its regulation in human cells
DNA replication stress promotes cancer development and is associated with DNA synthesis beyond S-phase. Replication stress-induced DNA lesions and under-replicated DNA can persist into G2 and mitosis, where they undergo mitotic DNA synthesis (MiDAS). After cell division, inherited DNA lesions are pr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD069739 | Pride
ProteomicsCharacterization of post-mitotic DNA synthesis and its regulation in human cells
DNA replication stress promotes cancer development and is associated with DNA synthesis beyond S-phase. Replication stress-induced DNA lesions and under-replicated DNA can persist into G2 and mitosis, where they undergo mitotic DNA synthesis (MiDAS). After cell division, inherited DNA lesions are pr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD069592 | Pride
GenomicsChIPseq measurement of transcriptional engagement and replication stress at the Drosophila Mid-blastula Transition
These experiments measure genome-wide RNA Pol II binding in precisely staged wild-type embryos at five time points spanning the maternal to zygotic transition (nuclear cycles 12 through 14) of Drosophila melanogaster. In addition, RNA Pol II binding at nuclear cycle 13 is measured in embryos mutant ...
ORGANISM(S): Drosophila melanogaster 
2015-03-05 | E-GEOD-62925 | biostudies-arrayexpress
UnknownRPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.
Not available
S-EPMC4446429 | biostudies-literature
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