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TranscriptomicsGenome-associated RNA Polymerase II includes the dissociable Rpb4/7 subcomplex
Yeast RNA polymerase (Pol) II consists of a ten-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immuno-precipitation coupled to h...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-29 | E-GEOD-12060 | biostudies-arrayexpress
ProteomicsNumerous post-translational modifications of RNA polymerase II subunit Rpb4 link transcription to post-transcriptional mechanisms
Rpb4/7 binds RNA Polymerase II (Pol II) transcripts co-transcriptionally and accompanies them throughout their lives. By virtue of its capacity to interact with key regulators (e.g., Pol II, eIF3, Pat1) both temporarily and spatially, Rpb4/7 regulates the major stages of the mRNA lifecycle. Here we ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-09-25 | PXD020511 | Pride
Post-translational modifications Rpb4 Mrna 
TranscriptomicsRNA-seq of yeast cells with mutations of the Rpb4 E19-22 motif
RNA-seq was performed on yeast strains carrying two different mutations in the Rpb4 E19-22 motif (plus a control) to determine how this region affects mRNA buffering (the connection of mRNA synthesis and decay).
ORGANISM(S): Saccharomyces cerevisiae 
2020-10-18 | E-MTAB-9647 | biostudies-arrayexpress
TranscriptomicsRpb4 functions mainly in mRNA synthesis by RNA polymerase II
RNA polymerase II (Pol II) is the central enzyme that carries out eukaryotic mRNA transcription and consists of a 10-subunit catalytic core and a heterodimeric subcomplex of subunits Rpb4 and Rpb7 (Rpb4/7). Rpb4/7 has been proposed to shuttle from the nucleus to the cytoplasm, and to function there ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-05-09 | E-MTAB-2539 | biostudies-arrayexpress
GenomicsRpb4 and Puf3
Rpb4 and Puf3
PRJNA638290 | ENA
GenomicsPotential modulation of Puf3 chromatin association mediated by Rpb4
Potential modulation of Puf3 chromatin association mediated by Rpb4
PRJNA638298 | ENA
UnknownRpb4/7 facilitates RNA polymerase II CTD dephosphorylation.
Not available
S-EPMC4267648 | biostudies-literature
UnknownRpb4 subunit functions mainly in mRNA synthesis by RNA polymerase II.
Not available
S-EPMC4067182 | biostudies-literature
GenomicsGenome-associated RNA Polymerase II includes the dissociable Rpb4/7 subcomplex
Yeast RNA polymerase (Pol) II consists of a ten-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immuno-precipitation coupled to h...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-30 | GSE12060 | GEO
GenomicsPotential modulation of Puf3 chromatin association mediated by Rpb4
Gene expression involving RNA polymerase II is regulated by the concerted interplay between mRNA synthesis and degradation, a crosstalk where mRNA decay machinery impacts transcription and transcription machinery influences mRNA stability. Rpb4, and likely the dimer Rpb4/7 seem to be the central com...
ORGANISM(S): Saccharomyces cerevisiae 
2022-11-09 | GSE152093 | GEO
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