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GenomicsHomo sapiens isolate:RPMI8226 | breed:RPMI8226 | cultivar:RPMI8226
Homo sapiens isolate:RPMI8226 | breed:RPMI8226 | cultivar:RPMI8226 Raw sequence reads
PRJNA350365 | ENA
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic RPMI8226 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45388 | biostudies-arrayexpress
TranscriptomicsEffect of c-MET inhibitor SU11274 upon sensitive (RPMI8226) or multi-resistant (RPMI8226/R5) Multiple Myeloma cell lines
The c-MET signaling axis is increasingly implicated in tumorigenesis and chemioresistance. In this study, we investigated gene expression modifications induced by SU11274 (Selleck Chemicals, Boston, USA), a novel selective c-MET inhibitor, in a pair of isogenic multiple myeloma (MM) cell lines eithe...
ORGANISM(S): Homo sapiens 
2012-05-24 | E-GEOD-38204 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and exosomal miRNAs in hypoxia-resistant RPMI8226 cells
In multiple myeloma (MM), abnormal plasma cells interact with bone marrow (BM) stromal cells and vascular cells among others. A part of the BM milieu is considered highly hypoxic, and myeloma cells in situ may be influenced by circumstances other than normoxia in vitro. Hence, we attempted to confir...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-48909 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of RPMI8226 cells after knockdown of KDM3A and KLF2
Recent studies have implicated KDM3A, which catalyzes removal of H3K9 methylation, is associated with tumorigenesis. However, the biological role of KDM3A in multiple myeloma, has not been delineated. Here we identify KDM3A-KLF2-IRF4 axis dependence in multiple myeloma. We demonstrate that knockdown...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-55667 | biostudies-arrayexpress
GenomicsEffect of HAPLN1-PTR1 on RPMI8226 multiple myeloma cells
Effect of HAPLN1-PTR1 on RPMI8226 multiple myeloma cells
PRJNA836926 | ENA
ProteomicsAnalysis of immunoprecipitates of HA-EZH2 in RPMI8226 cells transfected with an HA-EZH2 plasmid using Coomassie blue staining and mass spectrometry.
The purpose of this project is to identify proteins that interact with EZH2 in the myeloma cell line RPMI8226, which will further allow us to analyze the downstream molecular mechanisms associated with EZH2.
ORGANISM(S): Homo sapiens (Human) 
2025-02-27 | PXD056039 | Pride
Human Myeloma cells Lc/ms/ms Ezh2 
ProteomicsModulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells
Multiple myeloma RPMI8226 cells adapted to growth in melphalan display a shift towards Warburg metabolism and modulated oxidative stress signaling. Inhibitors targeting specific enzymes in these pathways are selectively toxic to the melphalan-resistant cells. To investigate large scale alterations i...
ORGANISM(S): Homo sapiens (Human) 
2015-05-26 | PXD001276 | Pride
Metabolism Multiple myeloma Stress Silac Melphalan Rpmi8226 Oxidative Signaling Warburg 
GenomicsEffect of HAPLN1-PTR1 on STAT1 knockout RPMI8226 multiple myeloma cells
Effect of HAPLN1-PTR1 on STAT1 knockout RPMI8226 multiple myeloma cells
PRJNA994179 | ENA
TranscriptomicsEffect of c-MET inhibitor SU11274 upon sensitive (RPMI8226) or multi-resistant (RPMI8226/R5) Multiple Myeloma cell lines
The c-MET signaling axis is increasingly implicated in tumorigenesis and chemioresistance. In this study, we investigated gene expression modifications induced by SU11274 (Selleck Chemicals, Boston, USA), a novel selective c-MET inhibitor, in a pair of isogenic multiple myeloma (MM) cell lines eithe...
ORGANISM(S): Homo sapiens 
2012-05-25 | GSE38204 | GEO
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