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ProteomicsModulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells
Multiple myeloma RPMI8226 cells adapted to growth in melphalan display a shift towards Warburg metabolism and modulated oxidative stress signaling. Inhibitors targeting specific enzymes in these pathways are selectively toxic to the melphalan-resistant cells. To investigate large scale alterations i...
ORGANISM(S): Homo sapiens (Human) 
2015-05-26 | PXD001276 | Pride
Metabolism Multiple myeloma Stress Silac Melphalan Rpmi8226 Oxidative Signaling Warburg 
ProteomicsMetabolic Changes Contribute to Melphalan Resistance in Multiple Myeloma
Multiple myeloma is an incurable hematological malignancy that impacts tens of thousands of people every year in the U.S. Treatment for eligible patients includes three stages: induction, consolidation with stem cell rescue, and maintenance. High dose therapy with the DNA alkylating agent, melphalan...
ORGANISM(S): Homo sapiens (Human) 
2020-07-17 | PXD019725 | Pride
Abpp Melphalan Proteomics Multiple myeloma Lc-ms/ms 
TranscriptomicsMelphalan-treated human retinal endothelial cells
Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an organ-specific drug-delivery strategy to treat retinoblastoma, the most common primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most...
ORGANISM(S): Homo sapiens 
2011-12-13 | E-GEOD-34381 | biostudies-arrayexpress
TranscriptomicsExpression data from cell lines originating from patients with multiple myeloma, plasmacytoma and diffuse large B-cell lymphoma
A predictive gene list for response to high dose melphalan therapy in patients diagnosed with multiple myeloma is generated by combining results from dose response experiments and microarray data using a B-cell line panel and the introduction of multivariate regression techniques. 18 malignant B-cel...
ORGANISM(S): Homo sapiens 
2011-04-30 | E-GEOD-22759 | biostudies-arrayexpress
TranscriptomicsPhase II trial melphalan ILI plus ADH-1 for treatment of in-transit extremity melanoma
An evaluation of biopsies from patients with in-transit extremity melanoma who have been treated with ADH-1 followed by melphalan in the setting of isolated limb infusion Gene expression profiles were obtained from 28 lesions across 15 patients and evaluated for expression values that correlated wit...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22968 | biostudies-arrayexpress
GenomicsT-cells' gene expression after high-dose melphalan
T-cells' gene expression after high-dose melphalan
PRJNA625689 | ENA
TranscriptomicsTranscription profiling of rat animal model of extremity melanoma after treatment with ADH-1 in combination with melphalan
To identify patterns of change in gene expression that correlated with drug treatment (saline control, ADH-1 alone, melphalan alone and ADH-1 plus melphalan) in our animal model of regional therapy for extremity melanoma we evaluated gene expression using microarray genechips and a Pearson correlati...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-8615 | biostudies-arrayexpress
GenomicsTak1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan
Tak1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan
PRJNA738364 | ENA
GenomicsProtective effects on melphalan-induced mouse intestinal injury treated by Human Umbilical Cord-derived Mesenchymal Stem Cells
Protective effects on melphalan-induced mouse intestinal injury treated by Human Umbilical Cord-derived Mesenchymal Stem Cells
PRJNA937919 | ENA
TranscriptomicsIn vivo study of ADH-1 in combination with melphalan for treatment of melanoma
To identify patterns of change in gene expression that correlated with drug treatment (saline control, ADH-1 alone, melphalan alone and ADH-1 plus melphalan) in our animal model of regional therapy for extremity melanoma we evaluated gene expression using microarray genechips and a Pearson correlati...
ORGANISM(S): Homo sapiens 
2008-10-30 | GSE8615 | GEO
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