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ProteomicsCross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 (without substrate).
This project investigates how the human 26S proteasome recognizes and processes proteins tagged with K11/K48-branched ubiquitin chains, which signal for rapid degradation during cell cycle progression and proteotoxic stress. Using cryo-electron microscopy (cryo-EM), the study uncovers a novel K11-li...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD064931 | Pride
Rpn13 Proteasome Uchl5 26s 
ProteomicsCross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 (with substrate).
This project investigates how the human 26S proteasome recognizes and processes proteins tagged with K11/K48-branched ubiquitin chains, which signal for rapid degradation during cell cycle progression and proteotoxic stress. Using cryo-electron microscopy (cryo-EM), the study uncovers a novel K11-li...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD064932 | Pride
K11/k48 ubiquitin Rpn13 Proteasome Uchl5 26s Branched ubiquitin 
UnknownProteasome subunit Rpn13 is a novel ubiquitin receptor.
Not available
S-EPMC2839886 | biostudies-literature
UnknownMechanism of the Rpn13-induced activation of Uch37.
Not available
S-EPMC4130924 | biostudies-literature
UnknownPhysical and Functional Analysis of the Putative Rpn13 Inhibitor RA190.
Not available
S-EPMC7680414 | biostudies-literature
UnknownBinding of SGTA to Rpn13 selectively modulates protein quality control.
Not available
S-EPMC4582187 | biostudies-literature
ProteomicsCross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 (without substrate).
Cross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 without added substrate.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-16 | MSV000092664 | MassIVE
UnknownPhosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation.
Not available
S-EPMC3009868 | biostudies-literature
ProteomicsCross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 (with substrate).
Cross-link MS analysis of human 26S proteasome in complex with RPN13:UCHL5 with the added ubiquitinated Sic1PY substrate.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-16 | MSV000092665 | MassIVE
UnknownRegulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
Not available
S-EPMC2965108 | biostudies-literature
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