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ProteomicsAltered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in hi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD010924 | Pride
Chronic lymphocytic leukemia Translational fidelity Ribosomal decoding center Cll Rps15 Proteostasis 
UnknownRPS15 mutations rewire RNA translation in chronic lymphocytic leukemia.
Not available
S-EPMC8288675 | biostudies-literature
GenomicsRps15 mutation drives B cell malignancy through translational rewiring, oxidative stress and genomic instability
Rps15 mutation drives B cell malignancy through translational rewiring, oxidative stress and genomic instability
PRJNA1246569 | ENA
OtherA RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects
Various somatic deletions and point mutations targeting ribosomal proteins (RPs) have been identified in cancer. To assess how these affect ribosomal translation, we applied genomewide translatome analysis (proteome, Ribo-seq and total RNA-seq) on an isogenic cell line library modeling the most recu...
ORGANISM(S): Mus musculus 
2025-11-18 | GSE310057 | GEO
ProteomicsMutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability
Ribosomal protein mutations are increasingly associated with cancer risk and thought to perturb ribosome function. At the same time, they reportedly activate p53, a critical anti-cancer barrier. To determine how these mutations overcome this protective block to enable tumorigenesis, we generated an ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD071901 | Pride
Mouse Ribosomal protein mutations Chronic lymphocytic leukemia 
GenomicsA RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects
A RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects
PRJNA1365082 | ENA
TranscriptomicsRps15 mutation drives B cell malignancy through translational rewiring, oxidative stress and genomic instability
Ribosomal protein mutations are increasingly associated with cancer risk and thought to perturb ribosome function. At the same time, they reportedly activate p53, a critical anti-cancer barrier. To determine how these mutations overcome this protective block to enable tumorigenesis, we generated an ...
ORGANISM(S): Mus musculus 
2025-06-01 | GSE293841 | GEO
UnknownThe C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation.
Not available
S-EPMC9037480 | biostudies-literature
Genomicsundefined
RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia
PRJEB48907 | ENA
UnknownAltered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.
Not available
S-EPMC6410914 | biostudies-literature
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