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In recent years, there is emerging pool of evidence suggesting that ribosomal composition plays a role in selection of transcripts that are actively translated at given time and tissue. Some ribosomal subunits are not the core components of 40S ribosome and alternatively can be assembled or disassem...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD047397 | Pride
Analysis of the role of RPS26 during translation in HEK293T RPS26 p.100_M115 del cells by 48S footprinting (TCP-seq)
The “Kozak sequence”, immediately upstream of the start codon, regulates the translational efficiency of an mRNA. Nevertheless, how this sequence is recognized remains unexplored. Here, we describe a novel approach to separate two ribosome populations from the same cells and use this method, and RNA...
ORGANISM(S): Saccharomyces cerevisiae 
2017-07-30 | GSE86203 | GEO
The ribosome mRNA channel is central for translation, but its role in specific regulatory mechanisms remains unexplored. Using Cryo-EM ribosomal complexes bound to Kozak and TISU mRNAs from WT and RPS26dC mutant cells, we demonstrate that RPS26 adopts distinct conformations, providing the basis for ...
ORGANISM(S): Homo sapiens 
2026-07-15 | GSE294217 | GEO
Diamond Blackfan anemia is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, often with associated physical abnormalities. Perturbations of the ribosome appear critically important to the development of DBA, as alterations in 9 different ribosomal protein genes ha...
ORGANISM(S): Homo sapiens 
Proteomics analysis of late human pre-40S particles purified using a catalytically-inactive RIO1 as bait. Analysis of RIO1(kd)-StHA pre-40S particles composition upon RPS26 depletion with siRNA.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD019270 | Pride
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