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CENP-A, a variant of histone H3, is incorporated into centromeric chromatin and plays a role during kinetochore establishment. In fission yeast, the localization of CENP-A is limited to a region spanning 10 to 20 kb of the core domain of the centromere. Here, we report a mutant (rpt3-1) in which thi...
ORGANISM(S): Schizosaccharomyces pombe 
CENP-A, a variant of histone H3, is incorporated into centromeric chromatin and plays a role during kinetochore establishment. In fission yeast, the localization of CENP-A is limited to a region spanning 10 to 20 kb of the core domain of the centromere. Here, we report a mutant (rpt3-1) in which thi...
ORGANISM(S): Schizosaccharomyces pombe 
2014-04-07 | GSE44594 | GEO
The 26S proteasome is the main proteolytic machine involved in protein degradation, contributing to homeostasis or stress response of eukaryotic cells. This macromolecular complex, consisting of a 20S core particle assembled with one or two 19S regulatory particles, is highly regulated by phos-phory...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-03 | PXD044616 | Pride
The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin
The ubiquitin-proteasome and autophagy-lysosome pathways are the two major routes for protein and organelle clearance. In skeletal muscle, both systems’ excessive activation induces severe muscle loss. Although altered proteasomal function has been observed in various myopathies, the specific role o...
ORGANISM(S): Mus musculus 
Adult muscle stem cells (satellite cells) are required for adult skeletal muscle regeneration. A proper balance between quiescence, proliferation, and differentiation is essential for the maintenance of the satellite cell pool and their regenerative function. Although the ubiquitin-proteasome is req...
ORGANISM(S): Mus musculus 
2018-10-10 | GSE114354 | GEO
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