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ProteomicsComposition of Arabidopsis RNA exosomes having incorporated wild type or mutated myc-tagged RRP41 proteins
RRP41 is one of the nine subunits constituting the core complex of the eukaryotic RNA exosome. Data presented here allowed a proteomic characterization of the interactome of wild type or mutated myc-tagged RRP41 proteins incorporated into the RNA exosome. Flowers from myc-tagged RRP41 expressing lin...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-01-02 | PXD007984 | Pride
Arabidopsis Rna degradation Rrp41 Rna exosome 
TranscriptomicsGlobal analysis of the nuclear processing of unspliced U12-type introns by the exosome
we analyzed globally the effect of exosome processing on the nuclear pre-mRNA transcripts by inactivating either the RRP41 or DIS3 subunit of the exosome. Using SOLiD RNA sequencing technology, we report 30-120 million mapped cellular compartment specific reads per sample allowing the detection of u...
ORGANISM(S): Homo sapiens 
2014-05-26 | E-GEOD-52539 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide Analysis of Exosome Targets in the Budding Yeast Saccharomyces cerevisiae
Purpose: The exosome plays major roles in RNA processing and surveillance but the in vivo target range and substrate acquisition mechanisms remain unclear. We applied an in vivo cross-linking technique coupled with deep sequencing (CRAC) that captures transcriptome-wide interactions between individu...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-25 | E-GEOD-40046 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the nuclear processing of unspliced U12-type introns by the exosome
we analyzed globally the effect of exosome processing on the nuclear pre-mRNA transcripts by inactivating either the RRP41 or DIS3 subunit of the exosome. Using SOLiD RNA sequencing technology, we report 30-120 million mapped cellular compartment specific reads per sample allowing the detection of u...
ORGANISM(S): Homo sapiens 
2014-05-26 | GSE52539 | GEO
UnknownA biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation.
Not available
S-EPMC11357806 | biostudies-literature
TranscriptomicsHigh density mapping of 3' extremities of 5.8S rRNA maturation precursors in Arabidopsis exosome mutants
The Arabidopsis core exosome (Exo9) has a phosphorolytic activity due to the RRP41 subunit. The goal of this experiment was to determine the role of this intrinsic activity of Exo9 on the maturation of the 5.8S rRNA in Arabidopsis.
ORGANISM(S): Arabidopsis thaliana 
2017-12-18 | GSE96946 | GEO
TranscriptomicsHigh density mapping of 3' extremities of rRNA maturation by-products in Arabidopsis exosome mutants
The Arabidopsis core exosome (Exo9) has a phosphorolytic activity due to the RRP41 subunit. The goal of this experiment was to determine the role of this intrinsic activity of Exo9 on the degradation of rRNA maturation by-products in Arabidopsis.
ORGANISM(S): Arabidopsis thaliana 
2017-12-18 | GSE96947 | GEO
OtherTranscriptome-wide analysis of alternative routes for RNA substrates into the exosome complex
The RNA exosome complex functions in both the accurate processing and rapid degradation of many different classes of RNA. Functional and structural analyses indicate that RNA can either be threaded through the central channel of the exosome or more directly access the active sites of the ribonucleas...
ORGANISM(S): Saccharomyces cerevisiae 
2017-03-20 | GSE90647 | GEO
UnknownTranscript-specific decapping and regulated stability by the human Dcp2 decapping protein.
Not available
S-EPMC2223397 | biostudies-literature
UnknownTranscriptome-wide analysis of alternative routes for RNA substrates into the exosome complex.
Not available
S-EPMC5389853 | biostudies-literature
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