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ProteomicsStress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.
Endoplasmic Reticulum (ER) stress is a hallmark of various diseases, which is dealt with through the activation of an adaptive signaling pathway named the Unfolded Protein Response (UPR). This response is mediated by three ER-resident sensors and the most evolutionary conserved, IRE1α signals throug...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-21 | PXD023433 | Pride
Upr Xbp1s Endoplasmic reticulum 
TranscriptomicsThe RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in C. elegans for the con...
ORGANISM(S): Caenorhabditis elegans 
2014-09-24 | E-GEOD-61733 | biostudies-arrayexpress
TranscriptomicsThe RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in C. elegans for the con...
ORGANISM(S): Caenorhabditis elegans 
2014-09-24 | GSE61733 | GEO
UnknownRTCB Complex Regulates Stress-Induced tRNA Cleavage.
Not available
S-EPMC9655011 | biostudies-literature
GenomicsRNA Ligase RTCB-mediated mRNA Alternative Splicing is Required for Mouse Oocyte Development and Maintenance
RNA Ligase RTCB-mediated mRNA Alternative Splicing is Required for Mouse Oocyte Development and Maintenance
PRJNA787956 | ENA
UnknownStructures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation.
Not available
S-EPMC3670941 | biostudies-literature
UnknownA synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.
Not available
S-EPMC4156904 | biostudies-literature
UnknownThe RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
Not available
S-EPMC4264930 | biostudies-literature
UnknownStructural and mechanistic insights into activation of the human RNA ligase RTCB by Archease.
Not available
S-EPMC10944509 | biostudies-literature
UnknownRtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo.
Not available
S-EPMC3162383 | biostudies-literature
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