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TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DAX]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44949 | biostudies-arrayexpress
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DYG]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44950 | biostudies-arrayexpress
ProteomicsEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed on a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteostasis and cell function. The UPR is initiated...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD022554 | Pride
Xbp1 Huntington`s disease Atf6 Upr Parkinson`s disease Er stress Protein aggregation 
GenomicsXBP1s cutnrun
XBP1s cutnrun
PRJNA949270 | ENA
GenomicsRNA-Seq of XBP1S and ATF6N cardiomyocytes
RNA-Seq of XBP1S and ATF6N cardiomyocytes
PRJNA813138 | ENA
GenomicsXBP1s cutnrun
XBP1s cutnrun
PRJNA887070 | ENA
ProteomicsContribution of the Unfolded Protein Response (UPR) transcription factor XBP1 to brain aging
In this project we aimed to evaluate the contribution of endoplasmic reticulum stress sensor IRE1 and its downstream transcription factor XBP1s to mammalian brain aging. We compared traits associated to aging at behavioral, electrophysiological, morphological and proteomic levels. We used transgenic...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-04 | PXD020539 | Pride
Unfolded protein response Xbp1s Dementia Aging 
GenomicsXBP1s Activation Globally Remodels N-Glycan Structure Distribution Patterns
XBP1s Activation Globally Remodels N-Glycan Structure Distribution Patterns
PRJNA448415 | ENA
GenomicsPharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
PRJNA625752 | ENA
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