CD4 T cell help requires functional SNARE protein SYNTAXIN-11 for successful interaction with B cells, CD40L mobilization and secretion of IL-2 and IL-10 to promote B cell differentiation, germinal centre formation and class switch. STX11-deficieny results in hypogammaglobulinemia suggesting a highe...
ORGANISM(S): Mus Musculus (ncbitaxon:10090)