Sort   by:  
 Page size 
The human glucocorticoid receptor (GR) is expressed as two alternately spliced Cterminal isoforms: α and β. In contrast to the canonical hGRα, hGRβ is constitutively nuclear, is not thought to bind ligand, and is believed to affect gene transcription only by acting as a dominant negative to hGRÎ...
ORGANISM(S): Homo sapiens 
In lymphomas derived from mature B cells the expression of the transcription factor PAX5 is maintained whereas classical Hodgkin lymphoma displays significantly reduced PAX5 expression despite its derivation from mature B cells. To elucidate the functional role of PAX5 in classical Hodgkin lymphoma,...
ORGANISM(S): Homo sapiens 
Ovarian cancer is a nearly uniform lethal disease and its highly aggressive metastatic phenotype portends a poor prognosis. Lack of a well-controlled, relevant experimental model has been a major obstacle to identifying key molecules causing metastasis. Here we describe the creation of a new isogeni...
ORGANISM(S): Homo sapiens (Human) 
2017-07-03 | PXD006327 | Pride
Flagella are essential for motility and pathogenicity in many bacteria. The main component of the flagellar filament, flagellin, often undergoes post-translational modifications, with glycosylation being a common occurrence. In Pseudomonas aeruginosa PAO1, the b-type flagellin is O-glycosylated with...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-05-07 | PXD056085 | Pride
CD4 T cell help requires functional SNARE protein SYNTAXIN-11 for successful interaction with B cells, CD40L mobilization and secretion of IL-2 and IL-10 to promote B cell differentiation, germinal centre formation and class switch. STX11-deficieny results in hypogammaglobulinemia suggesting a highe...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-03-01 | MSV000094210 | MassIVE
Mucosal-Associated Invariant T cells (MAIT cells) have a unique specificity for the microbial metabolite 5-OP-RU presented by the non-classical presentation molecule MR1. Upon activation, they release cytotoxic mediators and engage an antimicrobial activity. As a subset of T lymphocytes, MAIT develo...
ORGANISM(S): Mus musculus 
Sort   by:  
 Page size