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ProteomicsMapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance
Genomic and transcriptomic alterations are insufficient to explain the variance in protein expression seen in cancer. Recent evidence has highlighted the role of N6-methyladenosine (m6A) in the regulation of mRNA expression, stability and translation, supporting a potential role for post-transcripti...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD022348 | Pride
Prostate cancer M6a Mettl3 
TranscriptomicsMolecular Sampling of Prostate Cancer: a dilemma for predicting disease progression
Current prostate cancer prognostic models are based on pre-treatment prostate-specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict clinical disease progression. Hence, we sought to develop a molecular panel for prostate cancer...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-16560 | biostudies-arrayexpress
TranscriptomicsTMPRSS2-ERG fusion prostate cancer is a molecularly distinct estrogen-sensitive subclass of aggressive prostate cancer
Common epithelial cancers are believed to become more aggressive through the accumulation of multiple independent molecular events that lead to the deregulation of cell signaling. However, the discovery that the majority of prostate cancers harbor gene fusions of the 5'-untranslated region of androg...
ORGANISM(S): Homo sapiens 
2008-05-27 | E-GEOD-8402 | biostudies-arrayexpress
ProteomicsMinor intron splicing efficiency increases with the development of lethal prostate cancer
Minor intron-containing genes (MIGs) are crucial cell cycle regulators and are essential for cell survival. Thus, we explored whether MIGs play a role in cancer progression and cancer therapy resistance. Here we show that MIG-expression segregates sensitive and resistant prostate cancer cells from e...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD026949 | Pride
Minor spliceosome Lineage plasticity Minor intron genes U6atac Prostate cancer 
UnknownRisk factors for GI adverse events in a phase III randomized trial of bevacizumab in first-line therapy of advanced ovarian cancer: A Gynecologic Oncology Group Study.
Not available
S-EPMC3986384 | biostudies-literature
GenomicsEpigenomic alterations in localized and advanced prostate cancer
Here we used Illumina NGS for high-throughput profiling of the DNA methylome in seven human benign prostate tissues, seven human primary prostate cancer and six human castration resistant prostate cancer patient samples. These data were used to profile the CpG cytosine methylation pattern at single ...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-41701 | biostudies-arrayexpress
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
GenomicsFusionSeq: a modular framework for finding gene fusions by analyzing Paired-End RNA-Sequencing data

We have developed FusionSeq to identify fusion transcripts from paired-end RNA-sequencing. FusionSeq includes filters to remove spurious candidate fusions with artifacts such as misalignments or random pairing of transcript fragments and it ranks candidates according to several statistics. It a...

phs000311.v1.p1 | EGA
TranscriptomicsWhole Transcriptome Amplification for Gene Expression Profiling and Development of Molecular Archives
Type of experiment: This study used microarray experiments to evaluate the reproducibility and fidelity of Whole Transcriptome Amplification (WTA). Experimental factors: This study contains multiple categories of microarray experiments. Self-self hybridizations from WTA amplified total RNA were p...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-2618 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of LNCaP cells treated with miR-31
To determine the altered microRNA expression signature in human prostate cancer compared to benign prostate tissue. To determine the altered mRNA expression signatures upon overexrpession miR-31 in prostate cancer cells. Two condition experiments:1) Total RNA from 21 pairs of prostate cancers and ma...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-36801 | biostudies-arrayexpress
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