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GenomicsEpigenomic alterations in localized and advanced prostate cancer
Here we used Illumina NGS for high-throughput profiling of the DNA methylome in seven human benign prostate tissues, seven human primary prostate cancer and six human castration resistant prostate cancer patient samples. These data were used to profile the CpG cytosine methylation pattern at single ...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-41701 | biostudies-arrayexpress
ProteomicsMapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance
Genomic and transcriptomic alterations are insufficient to explain the variance in protein expression seen in cancer. Recent evidence has highlighted the role of N6-methyladenosine (m6A) in the regulation of mRNA expression, stability and translation, supporting a potential role for post-transcripti...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD022348 | Pride
Prostate cancer M6a Mettl3 
TranscriptomicsTMPRSS2-ERG fusion prostate cancer is a molecularly distinct estrogen-sensitive subclass of aggressive prostate cancer
Common epithelial cancers are believed to become more aggressive through the accumulation of multiple independent molecular events that lead to the deregulation of cell signaling. However, the discovery that the majority of prostate cancers harbor gene fusions of the 5'-untranslated region of androg...
ORGANISM(S): Homo sapiens 
2008-05-27 | E-GEOD-8402 | biostudies-arrayexpress
ProteomicsRole of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance seen in 10% of these patients is through lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine pros...
ORGANISM(S): Homo sapiens (Human) 
2020-11-04 | PXD016861 | Pride
Swi/snf complex Lineage plasticity Prostate cancer Epigenetic 
ProteomicsMinor intron splicing efficiency increases with the development of lethal prostate cancer
Minor intron-containing genes (MIGs) are crucial cell cycle regulators and are essential for cell survival. Thus, we explored whether MIGs play a role in cancer progression and cancer therapy resistance. Here we show that MIG-expression segregates sensitive and resistant prostate cancer cells from e...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD026949 | Pride
Minor spliceosome Lineage plasticity Minor intron genes U6atac Prostate cancer 
GenomicsRapid and Pervasive Changes in Genome-Wide Enhancer Usage During Mammalian Development
Here we used epigenomic profiling for H3K27ac, a mark of active enhancers to examine the genome-wide in vivo utilization of enhancers in three different mouse tissues across seven developmental stages, ranging from mid-gestation through adulthood. The majority of the ~90,000 enhancers identified exh...
ORGANISM(S): Mus musculus 
2013-12-19 | E-GEOD-52386 | biostudies-arrayexpress
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
TranscriptomicsMolecular Sampling of Prostate Cancer: a dilemma for predicting disease progression
Current prostate cancer prognostic models are based on pre-treatment prostate-specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict clinical disease progression. Hence, we sought to develop a molecular panel for prostate cancer...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-16560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse high and low exploratory genetically identical animals
Genetically identical inbred mice exhibit substantial stable individual variability in exploratory behavior. We used microarrays to look at gene expression differences in the hippocampus in female mice separated by stable differences in exploratory behavior Experiment Overall Design: Balb c/J offsp...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-11680 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Balb c/J offspring subjected to postnatal handling vs. controls
Postnatal handling in rodents leads to decreased anxiety-like behavior in adulthood. We used microarrays to look at gene expression differences in the CA1 region of the hippocampus in female mice subjected to postnatal handling compared to controls. Experiment Overall Design: Balb c/J offspring wer...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-11679 | biostudies-arrayexpress
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