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TranscriptomicsCulture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo
Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress
TranscriptomicsAn RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex
Purpose: To better understand the function of the various cell types of the brain, we prospectively purified neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendrocytes, myelinating oligodendrocytes, microglia, endothelial cells, and pericytes from mouse cerebral cortex. We g...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-52564 | biostudies-arrayexpress
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Cell Model]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78959 | biostudies-arrayexpress
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Treatment]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78960 | biostudies-arrayexpress
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