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TranscriptomicsGenome-wide RNA polymerase II recruitment study during the intraerythrocytic life cycle of Plasmodium falciparum.
We exploited the phosphorylation state of the RNAPII CTD to assess the transcriptional status of most P. falciparum genes across the IDC. We raised highly specific monoclonal antibodies against three forms of the parasite CTD, namely unphosphorylated, Ser5-P and Ser2/5-P, and used these in ChIP-on-c...
ORGANISM(S): Plasmodium falciparum 
2014-11-19 | E-GEOD-57748 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse colon dendritic cell subsets
Characterization of colon CD11chigh/MHCII+ myeloid cell subsets Colon lamina propria MHC+CD11chigh cells were sorted on the basis of CD103 and CD11b expression as follows: CD103+CD11b-, CD103+CD11b+, CD103-CD11b+.
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-58446 | biostudies-arrayexpress
TranscriptomicsSynergism between curdlan and GM-CSF in mouse dendritic cells
A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity for an efficient defence against distinct pathogens. For example, cross talk of TLR and c-type lectin signalling effectively shapes distinct gene expression patterns by integrating the sign...
ORGANISM(S): Mus musculus 
2011-10-14 | E-GEOD-32986 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small intestinal macrophages, neutrophils, CD103-CD11b+cDC and cryptopatch and ILF associated mononuclear phagocytes (CIA-MPh)
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. CIA-MPh expressed v...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9505 | biostudies-arrayexpress
TranscriptomicsCalcineurin/NFAT signaling inhibits myeloid hematopoiesis in mice.
Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signaling can also mediate granulocyte and DC activation, but it is unknown whether NFAT influences their development from progenitors. Here w...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-29094 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of small intestinal dendritic cells from C57BL/6, RORgt-/- and RORgt-Cre x Ltb-flox mice
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. We could demonstrat...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9522 | biostudies-arrayexpress
Transcriptomicstranscriptional profiling of NUP98-CDX1, NUP98-CDX4 and EGFP overexpressing primitive mouse bone marrow cells
The first genetic hits towards leukemia are thought often to confer to the mutant clone a slight proliferative/survial advantage. These pre-malignant clones can then be maintained under physiological cues in normal pool for long periods. We have searched for this type of first genetic hits and found...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-37900 | biostudies-arrayexpress
TranscriptomicsSingle-Cell RNA Sequencing of Mouse Synovial Tissue Across Developmental Time Points
Synovial joints harbor a protective lining layer, consisting of fibroblasts and macrophages, which form an epithelial-like barrier. In inflamed joints, lining macrophages regulate both early inflammatory cell influx and resolution. Despite these critical functions, it is currently unknown at what st...
ORGANISM(S): Mus musculus 
2026-06-09 | E-MTAB-17170 | biostudies-arrayexpress
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