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TranscriptomicsPost-transcriptional regulation of stress response in a myo1? mutant of the budding yeast Saccharomyces cerevisiae
The microarrays experiments of three biological and one technical replicates were performed in YJR12 (wt) and YJR13 (myo1?) strains. YJR12 (wild type) and YJR13 (myo1?) strains were obtained as haploid segregants from a cross between YJR6 (myo1::HIS5 strain) and BY4741 (obtained from ATTC). Cultures...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-08 | E-GEOD-20203 | biostudies-arrayexpress
UnknownSPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer.
Not available
S-EPMC12675285 | biostudies-literature
TranscriptomicsTranscription profiling of diagnostic tumoral samples in relation to primary response to drug treatment
Expression profile of diagnostic tumoral samples in relation to primary response to drug treatment
ORGANISM(S): Homo sapiens 
2005-10-30 | E-MEXP-388 | biostudies-arrayexpress
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
TranscriptomicsLow input Hi-C datasets for a diffuse large B-cell lymphoma sample, healthy control human B-cells and mouse embryonic stem cells
In this experiment, we've examined chromatin conformation of OG2 (B6; CBA-Tg(Pou5f1-EGFP)2Mnn/J; stock number 004654) mouse stem cells cultured as described in (Shi et al., 2008), using different amounts of starting cells. We performed a modified in situ Hi-C protocol for 6 samples digested with Mbo...
ORGANISM(S): Mus musculus 
2018-11-30 | E-MTAB-5875 | biostudies-arrayexpress
TranscriptomicsActivin/Nodal-dependent N6-methyladenosine (m6A) deposition in human pluripotent stem cells
This experiment was designed to probe the function of Activin/Nodal signalling in the deposition of m6A in human pluripotent stem cells (hPSCs). hPSCs were cultured in presence of Activin or subjected to short-term inhibition of Activin/Nodal signalling for 2h using the receptor antagonist SB-431542...
ORGANISM(S): Homo sapiens 
2017-12-26 | E-MTAB-5229 | biostudies-arrayexpress
UnknownSystematic review of the needs and health-related quality of life domains relevant to people surviving cancer in Europe.
Not available
S-EPMC11982114 | biostudies-literature
ModelsWong2024 - Cytotoxicity Prediction from Human Cell Lines
The authors use a large dataset (>30k) to train an explainable graph-based model to identify potential antibiotics with low cytotoxicity. The model uses a substructure-based approach to explore the chemical space. Using this method, they were able to screen 283 compounds and identify a candidate act...
2024-05-13 | MODEL2405130002 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ModelsWong2024 - Discovery of a structural class of antibiotics with explainable deep learning
The authors use a large dataset (>30k) to train an explainable graph-based model to identify potential antibiotics with low cytotoxicity. The model uses a substructure-based approach to explore the chemical space. Using this method, they were able to screen 283 compounds and identify a candidate act...
2024-05-08 | MODEL2405080002 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
TranscriptomicsFour Hi-C datasets from mESCs and 2C-like cells generated by knocking down the histone chaperone CAF-1 in mESCs
In this experiment, we've examined chromatin conformation of mESCs and 2C-like cells generated from a CAF-1 knockdown. The method to generate the knockdown was described in (). We performed a modified in situ Hi-C protocol from (Rao et al., 2014) and that can be found in detail at (Díaz et al., 2017...
ORGANISM(S): Mus musculus 
2023-11-16 | E-MTAB-6330 | biostudies-arrayexpress
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