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TranscriptomicsAntisense Transcripts Impede Uridylation-induced Exonucleolytic Degradation to Generate Guide RNAs
Small non-coding RNA biogenesis typically involves cleavage of structured precursors by RNase III-like endonucleases. However, guide RNAs that direct U-insertion/deletion mRNA editing in mitochondria of trypanosomes maintain 5′ triphosphate characteristic of transcription start site and possess U-...
ORGANISM(S): Trypanosoma brucei 
2016-02-08 | E-GEOD-71292 | biostudies-arrayexpress
TranscriptomicsCAGE-seq of human colon cancer cell line (HCT116) upon TBX3 overexpression
The Wnt/β-catenin signaling pathway plays crucial roles in nearly all parts of embryonic development and adult stem cell homeostasis. Its aberrant activation has been linked to many diseases such as developmental irregularities and various severe forms of cancer, with colorectal cancer (CRC) as a pr...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-13647 | biostudies-arrayexpress
TranscriptomicsTime resolved ribosome profiling study of oxygen and glucose deprivation of rat pheochromocytoma cells
Oxygen and glucose metabolism plays a pivotal role in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) occurs during ischemia and stroke, resulting in extensive tissue injury and cell death. We applied time-resolved ribosome profiling technique to assess earl...
ORGANISM(S): Rattus norvegicus 
2015-04-10 | E-GEOD-60752 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of chronic inflammation-induced gene expression in primary hepatocytes
Analysis of whole genome expression changes in primary hepatocytes in response to chronic stimulation with inflammatory cytokines. We hypothesized that chronic treatment of primary hepatocytes with TNFα would result in a reprogramming of the cell's transcriptome to improve adaptation to the presenc...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-67422 | biostudies-arrayexpress
UnknownMicrowave bio-sensor based on symmetrical split ring resonator with spurline filters for therapeutic goods detection.
Not available
S-EPMC5608324 | biostudies-literature
UnknownPromoter-pervasive transcription causes RNA polymerase II pausing to boost DOG1 expression in response to salt
Not available
S-SCDT-10_15252-EMBJ_2022112443 | biostudies-other
TranscriptomicsGenome-wide analysis of chronic inflammation induced gene expression in livers isolated from either wild type or ApoE-Cyp7a1 transgenic animals.
Analysis of whole genome expression changes in livers from wild type animals and animals with a liver specific transgenic over expression of Cyp7a1. Mice were given a chronic, repetitive administration of LPS for 7 days. Our prior analysis had indicated that inflammation suppresses Cyp7a1 and that t...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-75477 | biostudies-arrayexpress
UnknownPhysicians report adopting safer opioid prescribing behaviors after academic detailing intervention.
Not available
S-EPMC6237655 | biostudies-literature
GenomicsX-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate t...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-33823 | biostudies-arrayexpress
TranscriptomicsGene induction by all trans retinoic acid (ATRA) and/or omentum culture supernatant in bone marrow derived macrophages (BMDMs)
BMDMs were stimulated with ATRA and/or omentum culture supernatant and gene expression was determined by Illumina microarray 8 BMDM Samples
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-56683 | biostudies-arrayexpress
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