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UnknownAbnormal islet sphingolipid metabolism in type 1 diabetes.
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S-EPMC6445476 | biostudies-literature
TranscriptomicsFoxA1 is a critical determinant of Estrogen Receptor function and endocrine response
This SuperSeries is composed of the following subset Series: GSE25314: FoxA1 is a critical determinant of Estrogen Receptor function and endocrine response (part I) GSE25315: FoxA1 is a critical determinant of Estrogen Receptor function and endocrine response (part II) Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-11-17 | E-GEOD-25316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human LNCaP cells treated with DHT, RTI-6413-018 or vehicle to identify useful Selective Androgen Receptor Modulators (SARMs)
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure ...
ORGANISM(S): Homo sapiens 
2007-12-19 | E-GEOD-4636 | biostudies-arrayexpress
TranscriptomicsThe role of Dichaete in transcriptional regulation the of Drosophila midline [simgal4]
Dichaete is a developmentally important transcription factor, known to be involved in basic biological processes including segmentation and nervous system development among others. The aim of this experiment was to gain further insight into the role of Dichaete during early embryogenesis, specifical...
ORGANISM(S): Drosophila melanogaster 
2013-07-22 | E-GEOD-49094 | biostudies-arrayexpress
TranscriptomicsThe role of Dichaete in transcriptional regulation the of Drosophila midline [prosGal4]
Dichaete is a developmentally important transcription factor, known to be involved in basic biological processes including segmentation and nervous system development among others. The aim of this experiment was to gain further insight into the role of Dichaete during early embryogenesis, specifical...
ORGANISM(S): Drosophila melanogaster 
2013-07-22 | E-GEOD-49071 | biostudies-arrayexpress
TranscriptomicsTranscription profiling timecourse of induced DACH1 expression in a human breast cancer cell line
The vertebrate homologues of Drosophila dachsund, DACH1 and DACH2, have been implicated as important regulatory genes in development. DACH1 plays a role in retinal and pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis. DACH proteins contain a domain (DS-domain) tha...
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-685 | biostudies-arrayexpress
TranscriptomicsInfluence of oxygen limitation, absence of the cytochrome bc1 complex and low pH on global gene expression in Gluconobacter oxydans 621H using DNA microarray technology
The genome-wide transcriptional responses of the strictly aerobic -proteobacterium Gluconobacter oxydans 621H to oxygen limitation, to the absence of the cytochrome bc1 complex, and to low pH were studied using DNA microarray analyses. Oxygen limitation caused expression changes of 486 genes, repres...
ORGANISM(S): Gluconobacter oxydans 621H 
2012-03-23 | E-GEOD-34294 | biostudies-arrayexpress
TranscriptomicsFoxA1 is a critical determinant of Estrogen Receptor function and endocrine response (part II)
Estrogen Receptor-a (ER) is the key feature in the majority of breast cancers and ER binding to the genome correlates with the Forkhead protein FOXA1 (HNF3a), but mechanistic insight is lacking. We now show that FOXA1 is the defining factor that governs differential ER-chromatin interactions. We sho...
ORGANISM(S): Homo sapiens 
2010-11-17 | E-GEOD-25315 | biostudies-arrayexpress
TranscriptomicsFoxA1 is a critical determinant of Estrogen Receptor function and endocrine response (part I)
Estrogen Receptor-a (ER) is the key feature in the majority of breast cancers and ER binding to the genome correlates with the Forkhead protein FOXA1 (HNF3a), but mechanistic insight is lacking. We now show that FOXA1 is the defining factor that governs differential ER-chromatin interactions. We sho...
ORGANISM(S): Homo sapiens 
2010-11-17 | E-GEOD-25314 | biostudies-arrayexpress
TranscriptomicsHeat shock experimental replicates
Heat stress experiments imposed on Buchnera aphidicola within intact Schizaphis graminum hosts. NOTE: normalized values in GEO are NOT those derived from intensive analyses described in paper. Please see Wilcox et al. 2002 for description. Keywords = reduced bacterial genome, stress response
ORGANISM(S): Buchnera aphidicola (Schizaphis graminum) 
2003-01-20 | E-GEOD-87 | biostudies-arrayexpress
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